このアイテムのアクセス数: 3

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
hepatmon.36821.pdf3.39 MBAdobe PDF見る/開く
タイトル: Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model
著者: Iskandarov, Emil
Kadaba Srinivasan, Pramod
Xin, Wang
Bleilevens, Christian
Afify, Mamdouh
Hamza, Astrit
Wei, Lai
Hata, Koichiro
Agayev, Boyukkishi
Tolba, Rene
著者名の別形: 秦, 浩一郎
キーワード: CGS21680
A2A Adenosine Receptors
liver Cirrhosis
liver Resection
Interleukin-6
発行日: 24-Jul-2016
出版者: Kowsar Medical Institute
誌名: Hepatitis Monthly
巻: 16
号: 8
論文番号: e36821
抄録: Objectives: To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on a bile-duct-ligated cirrhotic liver resection model in rats. Methods: Male Wistar rats were allotted into 3 groups (n = 7 per time-point): the control group, the bile duct ligation + CGS21680 group (BDL + CGS), and the bile duct ligation group (BDL). Biliary cirrhosis had been previously induced by ligature of the common bile duct in the BDL + CGS and BDL groups. After 2 weeks, the animals underwent partial hepatectomy (50%). The BDL + CGS group received a single dose of CGS21680 15 minutes prior to hepatectomy. Blood samples were collected and analyzed. Results: Aspartate transaminase levels were found to be lower in the control vs BDL groups (1, 3, and 24 h) (P < 0.01) and the BDL + CGS (1 and 3 hours) (P < 0.01) and BDL + CGS vs BDL (24 hours) (P < 0.05) groups. Hepatic flow was measured and BDL showed significantly lower values at the 3, 24, and 168 h time-points compared to the control (P < 0.01) and BDL + CGS groups (P < 0.05 at 3 and 168 hours; P < 0.01 at 24 h). O2C velocity was reduced in the BDL compared to the control group (P < 0.001 at 3 hours; P < 0.01 at 24 and 168 hours) and the BDL + CGS group (P < 0.01 at 24 hours). Interleukin-6 levels were abrogated in the BDL + CGS (P < 0.05) and control (P < 0.01) groups versus BDL. Histone-bound low-molecular-weight DNA fragments in the BDL + CGS (P < 0.01) and control (P < 0.05) groups were low compared to the BDL group. Conclusions: Administration of CGS21680, an adenosine receptor agonist, after the resection of bile-duct-ligated cirrhotic livers led to improved liver function, regeneration, and microcirculation.
著作権等: © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/227130
DOI(出版社版): 10.5812/hepatmon.36821
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。