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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41467-017-00433-7.pdf | 3.09 MB | Adobe PDF | 見る/開く |
| タイトル: | Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration |
| 著者: | Ichijo, Ryo    https://orcid.org/0000-0001-5983-6791 (unconfirmed)Kobayashi, Hiroki Yoneda, Saori Iizuka, Yui Kubo, Hirokazu Matsumura, Shigeru Kitano, Satsuki Miyachi, Hitoshi Honda, Tetsuya Toyoshima, Fumiko |
| 著者名の別形: | 一條, 遼 豊島, 文子 |
| キーワード: | Cell division Reproductive biology Skin stem cells |
| 発行日: | 11-Sep-2017 |
| 出版者: | Springer Nature |
| 誌名: | Nature Communications |
| 巻: | 8 |
| 論文番号: | 508 |
| 抄録: | The skin surface area varies flexibly in response to body shape changes. Skin homeostasis is maintained by stem cells residing in the basal layer of the interfollicular epidermis. However, how the interfollicular epidermal stem cells response to physiological body shape changes remains elusive. Here, we identify a highly proliferative interfollicular epidermal basal cell population in the rapidly expanding abdominal skin of pregnant mice. These cells express Tbx3 that is necessary for their propagation to drive skin expansion. The Tbx3+ basal cells are generated from Axin2+ interfollicular epidermal stem cells through planar-oriented asymmetric or symmetric cell divisions, and express transit-amplifying cell marker CD71. This biased division of Axin2+ interfollicular epidermal stem cells is induced by Sfrp1 and Igfbp2 proteins secreted from dermal cells. The Tbx3+ basal cells promote wound repair, which is enhanced by Sfrp1 and Igfbp2. This study elucidates the interfollicular epidermal stem cell/progeny organisation during pregnancy and suggests its application in regenerative medicine. |
| 記述: | 妊娠期に腹部の皮膚が広がる仕組みの一端をマウスで解明. 京都大学プレスリリース. 2017-09-13. |
| 著作権等: | © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/227149 |
| DOI(出版社版): | 10.1038/s41467-017-00433-7 |
| PubMed ID: | 28894084 |
| 関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2017-09-13 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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