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タイトル: | Population structure and local adaptation of MAC lung disease agent Mycobacterium avium subsp. hominissuis |
著者: | Yano, Hirokazu Iwamoto, Tomotada Nishiuchi, Yukiko Nakajima, Chie Starkova, Daria A. Mokrousov, Igor Narvskaya, Olga Yoshida, Shiomi Arikawa, Kentaro Nakanishi, Noriko Osaki, Ken Nakagawa, Ichiro https://orcid.org/0000-0001-6552-1702 (unconfirmed) Ato, Manabu Suzuki, Yasuhiko Maruyama, Fumito https://orcid.org/0000-0003-2347-616X (unconfirmed) |
著者名の別形: | 丸山, 史人 中川, 一路 |
キーワード: | NTM pulmonary disease homologous recombination pan genome Mycobacterium intracellulare genetic population structure DCT |
発行日: | 8-Sep-2017 |
出版者: | Oxford University Press (OUP) |
誌名: | Genome Biology and Evolution |
巻: | 9 |
号: | 9 |
開始ページ: | 2403 |
終了ページ: | 2417 |
抄録: | Mycobacterium avium subsp. hominissuis (MAH) is one of the most common nontuberculous mycobacterial species responsible for chronic lung disease in humans. Despite increasing worldwide incidence, little is known about the genetic mechanisms behind the population evolution of MAH. To elucidate the local adaptation mechanisms of MAH, we assessed genetic population structure, the mutual homologous recombination, and gene content for 36 global MAH isolates, including 12 Japanese isolates sequenced in the present study. We identified five major MAH lineages and found that extensive mutual homologous recombination occurs among them. Two lineages (MahEastAsia1 and MahEastAsia2) were predominant in the Japanese isolates. We identified alleles unique to these two East Asian lineages in the loci responsible for trehalose biosynthesis (treS and mak) and in one mammalian cell entry operon, which presumably originated from as yet undiscovered mycobacterial lineages. Several genes and alleles unique to East Asian strains were located in the fragments introduced via recombination between East Asian lineages, suggesting implication of recombination in local adaptation. These patterns of MAH genomes are consistent with the signature of distribution conjugative transfer, a mode of sexual reproduction reported for other mycobacterial species. |
記述: | 肺MAC症原因菌が進化する仕組みを解明. 京都大学プレスリリース. 2017-09-20 |
著作権等: | © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
URI: | http://hdl.handle.net/2433/227171 |
DOI(出版社版): | 10.1093/gbe/evx183 |
PubMed ID: | 28957464 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2017-09-20 |
出現コレクション: | 学術雑誌掲載論文等 |
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