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Title: Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles
Authors: Yamano, Emi
Sugimoto, Masahiro
Hirayama, Akiyoshi
Kume, Satoshi
Yamato, Masanori
Jin, Guanghua
Tajima, Seiki
Goda, Nobuhito
Iwai, Kazuhiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Fukuda, Sanae
Yamaguti, Kouzi
Kuratsune, Hirohiko
Soga, Tomoyoshi
Watanabe, Yasuyoshi
Kataoka, Yosky
Author's alias: 岩井, 一宏
Keywords: Diseases
Medical research
Issue Date: 11-Oct-2016
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 6
Thesis number: 34990
Abstract: Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive metabolomic analyses of 133 plasma samples obtained from CFS patients and healthy controls to establish an objective diagnosis of CFS. CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid (TCA) and urea cycles. The combination of ornithine/citrulline and pyruvate/isocitrate ratios discriminated CFS patients from healthy controls, yielding area under the receiver operating characteristic curve values of 0.801 (95% confidential interval [CI]: 0.711–0.890, P < 0.0001) and 0.750 (95% CI: 0.584–0.916, P = 0.0069) for training (n = 93) and validation (n = 40) datasets, respectively. These findings provide compelling evidence that a clinical diagnostic tool could be developed for CFS based on the ratios of metabolites in plasma.
Rights: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
DOI(Published Version): 10.1038/srep34990
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