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タイトル: | Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles |
著者: | Yamano, Emi Sugimoto, Masahiro Hirayama, Akiyoshi Kume, Satoshi Yamato, Masanori Jin, Guanghua Tajima, Seiki Goda, Nobuhito Iwai, Kazuhiro https://orcid.org/0000-0001-5620-5951 (unconfirmed) Fukuda, Sanae Yamaguti, Kouzi Kuratsune, Hirohiko Soga, Tomoyoshi Watanabe, Yasuyoshi Kataoka, Yosky |
著者名の別形: | 岩井, 一宏 |
キーワード: | Diseases Medical research |
発行日: | 11-Oct-2016 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 6 |
論文番号: | 34990 |
抄録: | Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive metabolomic analyses of 133 plasma samples obtained from CFS patients and healthy controls to establish an objective diagnosis of CFS. CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid (TCA) and urea cycles. The combination of ornithine/citrulline and pyruvate/isocitrate ratios discriminated CFS patients from healthy controls, yielding area under the receiver operating characteristic curve values of 0.801 (95% confidential interval [CI]: 0.711–0.890, P < 0.0001) and 0.750 (95% CI: 0.584–0.916, P = 0.0069) for training (n = 93) and validation (n = 40) datasets, respectively. These findings provide compelling evidence that a clinical diagnostic tool could be developed for CFS based on the ratios of metabolites in plasma. |
著作権等: | © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. |
URI: | http://hdl.handle.net/2433/227419 |
DOI(出版社版): | 10.1038/srep34990 |
PubMed ID: | 27725700 |
出現コレクション: | 学術雑誌掲載論文等 |
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