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タイトル: | Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons |
著者: | Onodera, Koun Baba, Shumpei Murakami, Akira Uemura, Tadashi https://orcid.org/0000-0001-7204-3606 (unconfirmed) Usui, Tadao https://orcid.org/0000-0002-0507-1495 (unconfirmed) |
著者名の別形: | 小野寺, 孝興 馬場, 俊平 上村, 匡 碓井, 理夫 |
発行日: | 23-Oct-2017 |
出版者: | eLife Sciences Organisation, Ltd. |
誌名: | eLife |
巻: | 6 |
論文番号: | e29754 |
抄録: | In Drosophila larvae, Class IV sensory neurons respond to noxious thermal stimuli and provoke heat avoidance behavior. Previously, we showed that the activated neurons displayed characteristic fluctuations of firing rates, which consisted of repetitive high-frequency spike trains and subsequent pause periods, and we proposed that the firing rate fluctuations enhanced the heat avoidance (Terada et al., 2016). Here, we further substantiate this idea by showing that the pause periods and the frequency of fluctuations are regulated by small conductance Ca2+-activated K+ (SK) channels, and the SK knockdown larvae display faster heat avoidance than control larvae. The regulatory mechanism of the fluctuations in the Class IV neurons resembles that in mammalian Purkinje cells, which display complex spikes. Furthermore, our results suggest that such fluctuation coding in Class IV neurons is required to convert noxious thermal inputs into effective stereotyped behavior as well as general rate coding. |
記述: | 神経活動の「波のうねり」が痛みの情報を担うしくみを解明. 京都大学プレスリリース. 2017-10-25. |
著作権等: | © 2017, Onodera et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
URI: | http://hdl.handle.net/2433/227724 |
DOI(出版社版): | 10.7554/eLife.29754 |
PubMed ID: | 29035200 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2017-10-25 |
出現コレクション: | 学術雑誌掲載論文等 |
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