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Title: Differential regulations of vestibulo-ocular reflex and optokinetic response by β- And α2-adrenergic receptors in the cerebellar flocculus
Authors: Wakita, Ryo
Tanabe, Soshi
Tabei, Kazunari
Funaki, Asako
Inoshita, Takuma  kyouindb  KAKEN_id
Hirano, Tomoo
Author's alias: 田辺, 創思
舟木, 麻子
井下, 拓真
平野, 丈夫
Keywords: Cerebellum
Short-term memory
Vestibuloocular reflex
Issue Date: 21-Jun-2017
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 7
Thesis number: 3944
Abstract: Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of β- and α2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of β- or α2-adrenergic agonist or antagonist into the flocculus suggest that the β-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation of OKR, and that α2-adrenergic receptor counteracts the β-receptor activity in VOR and OKR control. We also examined effects of norepinephrine application, and the results suggest that norepinephrine regulates VOR and OKR through β-adrenergic receptor at low concentrations and through α2-receptor at high concentrations.
Rights: © 2017 The Author(s).
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DOI(Published Version): 10.1038/s41598-017-04273-9
PubMed ID: 28638085
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