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タイトル: Causes of Death in Patients with Severe Aortic Stenosis: An Observational study
著者: Minamino-Muta, Eri
Kato, Takao  kyouindb  KAKEN_id
Morimoto, Takeshi
Taniguchi, Tomohiko
Shiomi, Hiroki
Nakatsuma, Kenji
Shirai, Shinichi
Ando, Kenji
Kanamori, Norio
Murata, Koichiro
Kitai, Takeshi
Kawase, Yuichi
Miyake, Makoto
Izumi, Chisato
Mitsuoka, Hirokazu
Kato, Masashi
Hirano, Yutaka
Matsuda, Shintaro
Nagao, Kazuya
Inada, Tsukasa
Murakami, Tomoyuki
Takeuchi, Yasuyo
Yamane, Keiichiro
Toyofuku, Mamoru
Ishii, Mitsuru
Inoko, Moriaki
Ikeda, Tomoyuki
Komasa, Akihiro
Tada, Eiji
Ishii, Katsuhisa
Hotta, Kozo
Higashitani, Nobuya
Jinnai, Toshikazu
Kato, Yoshihiro
Inuzuka, Yasutaka
Maeda, Chiyo
Morikami, Yuko
Saito, Naritatsu
Sakata, Ryuzo
Minatoya, Kenji
Kimura, Takeshi
著者名の別形: 牟田, 恵里
加藤, 貴雄
木村, 剛
キーワード: Medical research
Valvular disease
発行日: 7-Nov-2017
出版者: Springer Nature
誌名: Scientific Reports
巻: 7
論文番号: 14723
抄録: Whether patients with severe aortic stenosis (AS) die because of AS-related causes is an important issue for the management of these patients. We used data from CURRENT AS registry, a Japanese multicenter registry, to assess the causes of death in severe AS patients and to identify the factors associated with non-cardiac mortality. We enrolled 3815 consecutive patients with a median follow-up of 1176 days; the 1449 overall deaths comprised 802 (55.3%) from cardiac and 647 (44.7%) from non-cardiac causes. Heart failure (HF) (25.7%) and sudden death (13.0%) caused the most cardiac deaths, whereas infection (13.0%) and malignancy (11.1%) were the main non-cardiac causes. According to treatment strategies, infection was the most common cause of non-cardiac death, followed by malignancy, in both the initial aortic valve replacement (AVR) cohort (N = 1197), and the conservative management cohort (N = 2618). Both non-cardiac factors (age, male, body mass index <22, diabetes, prior history of stroke, dialysis, anemia, and malignancy) and cardiac factors (atrial fibrillation, ejection fraction <68%, and the initial AVR strategy) were associated with non-cardiac death. These findings highlight the importance of close monitoring of non-cardiac comorbidities, as well as HF and sudden death, to improve the mortality rate of severe AS patients.
著作権等: © The Author(s) 2017
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/227888
DOI(出版社版): 10.1038/s41598-017-15316-6
出現コレクション:学術雑誌掲載論文等

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