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タイトル: | Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells |
著者: | Ikeda, Hiroki Sone, Masamitsu Yamanaka, Shinya Yamamoto, Takuya https://orcid.org/0000-0002-0022-3947 (unconfirmed) |
著者名の別形: | 池田, 宏輝 曽根, 正光 山中, 伸弥 山本, 拓也 |
キーワード: | Epigenomics Gene regulation Nuclear organization Pluripotent stem cells |
発行日: | 20-Nov-2017 |
出版者: | Springer Nature |
誌名: | Nature Communications |
巻: | 8 |
論文番号: | 1616 |
抄録: | Higher-order chromatin organization controls transcriptional programs that govern cell properties and functions. In order for pluripotent stem cells (PSCs) to appropriately respond to differentiation signals, developmental gene loci should be structurally and spatially regulated to be readily available for immediate transcription, even though these genes are hardly expressed in PSCs. Here, we show that both chromatin interaction profiles and nuclear positions at developmental gene loci differ between human somatic cells and hPSCs, and that changes in the chromatin interactions are closely related to the nuclear repositioning. Moreover, we also demonstrate that developmental gene loci, which have bivalent histone modifications, tend to colocalize in PSCs. Furthermore, this colocalization requires PRC1, PRC2, and TrxG complexes, which are essential regulatory factors for the maintenance of transcriptionally poised developmental genes. Our results indicate that higher-order chromatin regulation may be an integral part of the differentiation capacity that defines pluripotency. |
記述: | 多能性幹細胞における分化関連遺伝子座の染色体高次構造と核内配置の同定. 京都大学プレスリリース. 2017-11-20. |
著作権等: | © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/227917 |
DOI(出版社版): | 10.1038/s41467-017-01679-x |
PubMed ID: | 29158493 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2017-11-20 |
出現コレクション: | 学術雑誌掲載論文等 |
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