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| s41598-017-07137-4.pdf | 1.02 MB | Adobe PDF | 見る/開く |
| タイトル: | Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis |
| 著者: | Kuramoto, Nobuo Ohmura, Koichiro  Ikari, Katsunori Yano, Koichiro Furu, Moritoshi Yamakawa, Noriyuki Hashimoto, Motomu Ito, Hiromu Fujii, Takao Murakami, Kosaku   https://orcid.org/0000-0001-5981-4648 (unconfirmed)Nakashima, Ran Imura, Yoshitaka Yukawa, Naoichiro Yoshifuji, Hajime https://orcid.org/0000-0001-7082-4900 (unconfirmed)Taniguchi, Atsuo Momohara, Shigeki Yamanaka, Hisashi Matsuda, Fumihiko Mimori, Tsuneyo Terao, Chikashi |
| 著者名の別形: | 藏本, 伸生 大村, 浩一郎 布留, 守敏 山川, 範之 橋本, 求 伊藤, 宣 藤井, 隆夫 村上, 孝作 中嶋, 蘭 井村, 嘉孝 湯川, 尚一郎 吉藤, 元 松田, 文彦 三森, 経世 寺尾, 知可史 |
| キーワード: | Autoimmunity Rheumatoid arthritis |
| 発行日: | 31-Jul-2017 |
| 出版者: | Springer Nature |
| 誌名: | Scientific Reports |
| 巻: | 7 |
| 論文番号: | 6911 |
| 抄録: | Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9, 575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3, 353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features. |
| 著作権等: | © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/228140 |
| DOI(出版社版): | 10.1038/s41598-017-07137-4 |
| PubMed ID: | 28761166 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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