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Title: Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
Authors: Kuramoto, Nobuo
Ohmura, Koichiro  kyouindb  KAKEN_id
Ikari, Katsunori
Yano, Koichiro
Furu, Moritoshi
Yamakawa, Noriyuki
Hashimoto, Motomu  kyouindb  KAKEN_id
Ito, Hiromu
Fujii, Takao
Murakami, Kosaku  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5981-4648 (unconfirmed)
Nakashima, Ran
Imura, Yoshitaka
Yukawa, Naoichiro
Yoshifuji, Hajime  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7082-4900 (unconfirmed)
Taniguchi, Atsuo
Momohara, Shigeki
Yamanaka, Hisashi
Matsuda, Fumihiko
Mimori, Tsuneyo
Terao, Chikashi
Author's alias: 藏本, 伸生
大村, 浩一郎
布留, 守敏
山川, 範之
橋本, 求
伊藤, 宣
藤井, 隆夫
村上, 孝作
中嶋, 蘭
井村, 嘉孝
湯川, 尚一郎
吉藤, 元
松田, 文彦
三森, 経世
寺尾, 知可史
Keywords: Autoimmunity
Rheumatoid arthritis
Issue Date: 31-Jul-2017
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 7
Thesis number: 6911
Abstract: Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9, 575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3, 353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.
Rights: © The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/228140
DOI(Published Version): 10.1038/s41598-017-07137-4
PubMed ID: 28761166
Appears in Collections:Journal Articles

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