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Title: Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee
Authors: Hirata, Satoshi  kyouindb  KAKEN_id
Hirai, Hirohisa
Nogami, Etsuko
Morimura, Naruki  kyouindb  KAKEN_id
Udono, Toshifumi
Author's alias: 平田, 聡
平井, 啓久
野上, 悦子
森村, 成樹
鵜殿, 俊史
Keywords: Chimpanzee
Chromosomal abnormality
Down syndrome
Atrial septal defect
Issue Date: Apr-2017
Publisher: Springer Japan
Journal title: Primates
Volume: 58
Issue: 2
Start page: 267
End page: 273
Abstract: We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the second reported case of trisomy 22 in the chimpanzee. The chimpanzee in our case became blind by 7 years old, making social life with other chimpanzees difficult, but opportunities to interact with other conspecific individuals have been offered routinely. We believe that providing her with the best care over the course of her life will be essential.
Rights: The final publication is available at Springer via
The full-text file will be made open to the public on 01 April 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1007/s10329-017-0597-8
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