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タイトル: Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
著者: Goda, Tadahiro
Doi, Masao  kyouindb  KAKEN_id
Umezaki, Yujiro
Murai, Iori
Shimatani, Hiroyuki
Chu, Michelle L.
Nguyen, Victoria H.
Okamura, Hitoshi
Hamada, Fumika N.
著者名の別形: 合田, 忠弘
土居, 雅夫
梅崎, 勇次郎
村井, 伊織
嶋谷, 寛之
岡村, 均
濱田, 文香
キーワード: DH31R
Calcr
calcitonin receptor
circadian rhythm
body temperature rhythm
temperature preference rhythm
thermoregulation
発行日: 15-Jan-2018
出版者: Cold Spring Harbor Laboratory
誌名: Genes & Development
巻: 32
号: 2
開始ページ: 140
終了ページ: 155
抄録: Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
記述: マウスとハエに共通にみられる体温の日内リズムを制御する仕組み. 京都大学プレスリリース. 2018-02-14.
著作権等: © 2018 Goda et al.; Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
The full-text file will be made open to the public on 15 July 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
URI: http://hdl.handle.net/2433/229398
DOI(出版社版): 10.1101/gad.307884.117
PubMed ID: 29440246
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180214_1.html
出現コレクション:学術雑誌掲載論文等

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