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タイトル: | Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals |
著者: | Goda, Tadahiro Doi, Masao https://orcid.org/0000-0001-6264-9217 (unconfirmed) Umezaki, Yujiro Murai, Iori Shimatani, Hiroyuki Chu, Michelle L. Nguyen, Victoria H. Okamura, Hitoshi Hamada, Fumika N. |
著者名の別形: | 合田, 忠弘 土居, 雅夫 梅崎, 勇次郎 村井, 伊織 嶋谷, 寛之 岡村, 均 濱田, 文香 |
キーワード: | DH31R Calcr calcitonin receptor circadian rhythm body temperature rhythm temperature preference rhythm thermoregulation |
発行日: | 15-Jan-2018 |
出版者: | Cold Spring Harbor Laboratory |
誌名: | Genes & Development |
巻: | 32 |
号: | 2 |
開始ページ: | 140 |
終了ページ: | 155 |
抄録: | Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms. |
記述: | マウスとハエに共通にみられる体温の日内リズムを制御する仕組み. 京都大学プレスリリース. 2018-02-14. |
著作権等: | © 2018 Goda et al.; Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. The full-text file will be made open to the public on 15 July 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. |
URI: | http://hdl.handle.net/2433/229398 |
DOI(出版社版): | 10.1101/gad.307884.117 |
PubMed ID: | 29440246 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180214_1.html |
出現コレクション: | 学術雑誌掲載論文等 |
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