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Title: Nutrient-dependent increased dendritic arborization of somatosensory neurons
Authors: Watanabe, Kaori
Furumizo, Yuki
Usui, Tadao  kyouindb  KAKEN_id  orcid (unconfirmed)
Hattori, Yukako  kyouindb  KAKEN_id  orcid (unconfirmed)
Uemura, Tadashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 碓井, 理夫
服部, 佑佳子
上村, 匡
Issue Date: 12-Jan-2017
Publisher: Blackwell Publishing Ltd
Journal title: Genes to Cells
Volume: 22
Issue: 1
Start page: 105
End page: 114
Abstract: Suboptimal nutrition imposes developmental constraints on infant animals, which marshal adaptive responses to eventually become mature adults. Such responses are mounted at multiple levels from systemic to cellular. At the cellular level, the underlying mechanisms of cell proliferation control have been intensively studied. However, less is known about how growth of postmitotic and morphologically complex cells, such as neurons, is controlled by nutritional status. We address this question using Class I and Class IV dendritic arborization neurons in Drosophila larvae. Class IV neurons have been shown to sense nociceptive thermal, mechanical and light stimuli, whereas Class I neurons are proprioceptors. We reared larvae on diets with different protein and carbohydrate content throughout larval stages and examined how morphologies of Class I or Class IV neurons were affected. Dendritic arbors of Class IV neurons became more complex when larvae were reared on a low-yeast diet, which contains lower amounts of amino acids and other ingredients, compared to a high-yeast diet. In contrast, such low-yeast-dependent hyperarborization was not seen in Class I neurons. The physiological and metabolic implications of the hyperarborization phenotype are discussed in relation to a recent hypothesis that Class IV neurons sense protein-deficient stress and to our characterization of how the dietary yeast contents impacted larval metabolism.
Rights: This is the peer reviewed version of the following article: [Kaori Watanabe , Yuki Furumizo, Tadao Usui, Yukako Hattori, Tadashi Uemura (2016).Nutrient‐dependent increased dendritic arborization of somatosensory neurons, Genes to Cells, 22(1), 105-114], which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 12 January 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1111/gtc.12451
PubMed ID: 27868313
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