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タイトル: | iPSC technology-based regenerative therapy for diabetes |
著者: | Kondo, Yasushi Toyoda, Taro https://orcid.org/0000-0002-2948-0525 (unconfirmed) Inagaki, Nobuya Osafune, Kenji https://orcid.org/0000-0001-7238-2763 (unconfirmed) |
著者名の別形: | 豊田, 太郎 稲垣, 暢也 長船, 健二 |
キーワード: | Cell therapy Disease model Induced pluripotent stem cells |
発行日: | 4-Mar-2018 |
出版者: | Blackwell Publishing |
誌名: | Journal of Diabetes Investigation |
巻: | 9 |
号: | 2 |
開始ページ: | 234 |
終了ページ: | 243 |
抄録: | The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of the pancreas. Recent advances in this research field have enabled the generation from hESCs/iPSCs of functionally mature β‐like cells in vitro that show glucose‐responsive insulin secretion ability. The therapeutic potentials of hESC/iPSC‐derived pancreatic cells have been evaluated using diabetic animal models, and transplantation methods including immunoprotective devices that prevent immune responses from hosts to the implanted pancreatic cells have been investigated towards the development of regenerative therapies against diabetes. These efforts led to the start of a clinical trial that involves the implantation of hESC‐derived pancreatic progenitors into type 1 diabetes patients. In addition, patient‐derived iPSCs have been generated from diabetes‐related disorders towards the creation of novel in vitro disease models and drug discovery, although few reports so far have analyzed the disease mechanisms. Considering recent advances in differentiation methods that generate pancreatic endocrine lineages, we will see the development of novel cell therapies and therapeutic drugs against diabetes based on iPSC technology‐based research in the next decade. |
著作権等: | © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/230423 |
DOI(出版社版): | 10.1111/jdi.12702 |
PubMed ID: | 28609558 |
出現コレクション: | 学術雑誌掲載論文等 |
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