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Title: Bullous Pemphigoid associated with Dipeptidyl Peptidase-4 Inhibitors: A Report of Five Cases.
Authors: Yoshiji, Satoshi
Murakami, Takaaki
Harashima, Shinichi  kyouindb  KAKEN_id
Ko, Rie
Kashima, Riko
Yabe, Daisuke  kyouindb  KAKEN_id  orcid (unconfirmed)
Ogura, Masahito  kyouindb  KAKEN_id  orcid (unconfirmed)
Doi, Kentaro
Inagaki, Nobuya  kyouindb  KAKEN_id
Author's alias: 原島, 伸一
矢部, 大介
小倉, 雅仁
稲垣, 暢也
Keywords: Bullous pemphigoid
Dipeptidyl peptidase-4 inhibitors
Issue Date: 4-Mar-2018
Publisher: Wiley-Blackwell
Journal title: Journal of diabetes investigation
Volume: 9
Issue: 2
Start page: 445
End page: 447
Abstract: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population because of their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here, we report five Japanese cases of BP associated with the agents. In the present cases, BP occurred in older adults using four different DPP-4 inhibitors, which showed various clinical manifestations in terms of latency period for BP, sex, glycemic control and diabetes duration. Withdrawal of DPP-4 inhibitors was effective in improving BP, and achieved remission even in cases requiring oral steroid administration and intravenous immunoglobulin therapy. Clinicians should note the importance of early diagnosis of this clinical condition and initiate prompt withdrawal of DPP-4 inhibitors.
Rights: © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
DOI(Published Version): 10.1111/jdi.12695
PubMed ID: 28520234
Appears in Collections:Journal Articles

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