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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.ehpc.2017.10.004.pdf | 1.3 MB | Adobe PDF | 見る/開く |
| タイトル: | Membranous glomerulonephritis in a patient with anti-u1 ribonucleoprotein (RNP) antibody-positive mixed connective tissue disease: A case report |
| 著者: | Toriu, Naoya Hoshino, Junichi Hasegawa, Eiko Sumida, Keiichi Suwabe, Tatsuya Inenaga, Junichi Kawada, Masahiro Ueno, Toshiharu Kikuchi, Koichi Hayami, Noriko Sekine, Akinari Hiramatsu, Rikako Yamanouchi, Masayuki Sawa, Naoki Takaichi, Kenmei Ohashi, Kenichi Uesugi, Noriko Fujii, Takeshi Yanagita, Motoko    https://orcid.org/0000-0002-0339-9008 (unconfirmed)Ubara, Yoshifumi |
| 著者名の別形: | 柳田, 素子 |
| キーワード: | Membranous glomerulonephritis Mixed connective tissue disease |
| 発行日: | Mar-2018 |
| 出版者: | Elsevier BV |
| 誌名: | Human Pathology: Case Reports |
| 巻: | 11 |
| 開始ページ: | 43 |
| 終了ページ: | 46 |
| 抄録: | We report a 33-year-old Japanese man diagnosed with mixed connective tissue disease (MCTD) who developed nephrotic proteinuria. Both speckled antinuclear antibody (ANA) and anti-U1 ribonucleoprotein (RNP) antibody were positive, but anti-double-stranded DNA (dsDNA) antibody and anti-Smith (Sm) antibody were negative, while complement levels were normal. Renal biopsy revealed membranous glomerulonephritis (MGN) with diffuse thickening of the glomerular basement membrane (GBM) plus spike and bubble formation. Immunofluorescence demonstrated granular deposits of IgG and C3 along the GBM. Analysis of IgG subclasses showed predominant deposition of IgG1 and IgG4, unlike typical lupus nephritis in which there is predominant deposition of IgG1, IgG2, IgG3, and C1q. Electron microscopy identified numerous large electron-dense deposits (EDD) of various types in the subepithelial region of the GBM, but there were no EDD localized in the mesangium or subendothelium. Based on these findings, MGN was considered to be closely related to MCTD in this patient. |
| 著作権等: | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
| URI: | http://hdl.handle.net/2433/230438 |
| DOI(出版社版): | 10.1016/j.ehpc.2017.10.004 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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