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journal.pone.0191203.pdf | 6.76 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | S, Mohri | en |
dc.contributor.author | H, Takahashi | en |
dc.contributor.author | M, Sakai | en |
dc.contributor.author | S, Takahashi | en |
dc.contributor.author | N, Waki | en |
dc.contributor.author | K, Aizawa | en |
dc.contributor.author | H, Suganuma | en |
dc.contributor.author | T, Ara | en |
dc.contributor.author | Y, Matsumura | en |
dc.contributor.author | D, Shibata | en |
dc.contributor.author | T, Goto | en |
dc.contributor.author | T, Kawada | en |
dc.contributor.alternative | 毛利, 晋輔 | ja |
dc.contributor.alternative | 高橋, 春弥 | ja |
dc.contributor.alternative | 高橋, 慎吾 | ja |
dc.contributor.alternative | 脇, 尚子 | ja |
dc.contributor.alternative | 荒, 武 | ja |
dc.contributor.alternative | 松村, 康生 | ja |
dc.contributor.alternative | 柴田, 大輔 | ja |
dc.contributor.alternative | 後藤, 剛 | ja |
dc.contributor.alternative | 河田, 照雄 | ja |
dc.date.accessioned | 2018-04-20T01:41:57Z | - |
dc.date.available | 2018-04-20T01:41:57Z | - |
dc.date.issued | 2018-01-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/230702 | - |
dc.description.abstract | Obesity-induced chronic inflammation is a key factor in type 2 diabetes. A vicious cycle involving pro-inflammatory mediators between adipocytes and macrophages is a common cause of chronic inflammation in the adipose tissue. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, we focused on anti-inflammatory compounds in tomato. We found that the extract of tomato reduced plasma glucose and inflammatory markers in mice. We screened anti-inflammatory fractions in tomato using lipopolysaccharide-stimulated RAW264.7 macrophages, and active compounds were estimated by liquid chromatography-mass spectrometry over a wide range. Surprisingly, a large number of compounds including oxylipin and coumarin derivatives were estimated as anti-inflammatory compounds. Especially, 9-oxo-octadecadienoic acid and daphnetin suppressed pro-inflammatory cytokines in RAW264.7 macrophages inhibiting mitogen-activated protein kinase phosphorylation and inhibitor of kappa B α protein degradation. These findings suggest that tomato containing diverse anti-inflammatory compounds ameliorates chronic inflammation in obese adipose tissue. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | en |
dc.rights | © 2018 Mohri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PloS one | en |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.relation.doi | 10.1371/journal.pone.0191203 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e0191203 | - |
dc.address | Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University | en |
dc.address | Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University・KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University | en |
dc.address | Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University | en |
dc.address | Innovation Division, KAGOME CO., LTD. | en |
dc.address | KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University・ Innovation Division, KAGOME CO., LTD. | en |
dc.address | Innovation Division, KAGOME CO., LTD. | en |
dc.address | Innovation Division, KAGOME CO., LTD. | en |
dc.address | KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University | en |
dc.address | Laboratory of Quality Analysis and Assessment, Graduate School of Agriculture, Kyoto University | en |
dc.address | KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University・Kazusa DNA Research Institutes, Kazusa-Kamatari | en |
dc.address | Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University・Research Unit for Physiological Chemistry, Kyoto University | en |
dc.address | Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University・Research Unit for Physiological Chemistry, Kyoto University | en |
dc.identifier.pmid | 29329333 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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