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Title: Advancing small-molecule-based chemical biology with next-generation sequencing technologies
Authors: Anandhakumar, Chandran
Kizaki, Seiichiro
Bando, Toshikazu
Pandian, Ganesh N.
Sugiyama, Hiroshi  kyouindb  KAKEN_id
Author's alias: 板東, 俊和
杉山, 弘
Keywords: aptamers
chemical biology
genomics
next-generation sequencing
small molecules
Issue Date: 2-Jan-2015
Publisher: Wiley-VCH Verlag
Journal title: ChemBioChem
Volume: 16
Issue: 1
Start page: 20
End page: 38
Abstract: Next-generation-sequencing (NGS) technologies enable us to obtain extensive information by deciphering millions of individual DNA sequencing reactions simultaneously. The new DNA-sequencing strategies exceed their precursors in output by many orders of magnitude, resulting in a quantitative increase in valuable sequence information that could be harnessed for qualitative analysis. Sequencing on this scale has facilitated significant advances in diverse disciplines, ranging from the discovery, design, and evaluation of many small molecules and relevant biological mechanisms to maturation of personalized therapies. NGS technologies that have recently become affordable allow us to gain in-depth insight into small-molecule-triggered biological phenomena and empower researchers to develop advanced versions of small molecules. In this review we focus on the overlooked implications of NGS technologies in chemical biology, with a special emphasis on small-molecule development and screening.
Rights: This is the accepted version of the following article: [Chandran Anandhakumar, Seiichiro Kizaki, Toshikazu Bando, Ganesh N. Pandian, Hiroshi Sugiyama. Advancing Small‐Molecule‐Based Chemical Biology with Next‐Generation Sequencing Technologies. ChemBioChem (2015), 16, 1, 20-38], which has been published in final form at https://doi.org/10.1002/cbic.201402556. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 23 December 2015 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/230880
DOI(Published Version): 10.1002/cbic.201402556
PubMed ID: 25421391
Appears in Collections:Journal Articles

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