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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| chem.201600950.pdf | 1.46 MB | Adobe PDF | 見る/開く |
| タイトル: | Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA |
| 著者: | Zou, Tingting Kizaki, Seiichiro Pandian, Ganesh N. Sugiyama, Hiroshi    https://orcid.org/0000-0001-8923-5946 (unconfirmed) |
| 著者名の別形: | 杉山, 弘 |
| キーワード: | accessibility alkylation antitumor agents duocarmycin B2 nucleosome |
| 発行日: | 20-Jun-2016 |
| 出版者: | Wiley-VCH Verlag |
| 誌名: | Chemistry - A European Journal |
| 巻: | 22 |
| 号: | 26 |
| 開始ページ: | 8756 |
| 終了ページ: | 8758 |
| 抄録: | To evaluate the reactivity of antitumor agents in a nucleosome architecture, we conducted in vitro studies to assess the alkylation level of duocarmycin B2 on nucleosomes with core and linker DNA using sequencing gel electrophoresis. Our results suggested that the alkylating efficiencies of duocarmycin B2 were significantly decreased in core DNA and increased at the histone-free linker DNA sites when compared with naked DNA conditions. Our finding that nucleosome assembly alters the accessibility of duocarmycin B2 to duplex DNA could advance its design as an antitumor agent. |
| 著作権等: | This is the accepted version of the following article: [Tingting Zou, Seiichiro Kizaki, Ganesh N. Pandian, Hiroshi Sugiyama. Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA. ChemBioChem (2016), 22, 26, 8756-8758], which has been published in final form at https://doi.org/10.1002/chem.201600950. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 15 June 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/230882 |
| DOI(出版社版): | 10.1002/chem.201600950 |
| PubMed ID: | 27123891 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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