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タイトル: | Specific IgE for Fag e 3 Predicts Oral Buckwheat Food Challenge Test Results and Anaphylaxis: A Pilot Study |
著者: | Yanagida, Noriyuki Sato, Sakura Maruyama, Nobuyuki https://orcid.org/0000-0002-1369-9629 (unconfirmed) Takahashi, Kyohei Nagakura, Ken-ichi Ogura, Kiyotake Asaumi, Tomoyuki Ebisawa, Motohiro |
著者名の別形: | 丸山, 伸之 |
キーワード: | Buckwheat Food allergy Food hypersensitivity Oral food challenge Immunoglobulin E |
発行日: | May-2018 |
出版者: | S. Karger AG |
誌名: | International Archives of Allergy and Immunology |
巻: | 176 |
号: | 1 |
開始ページ: | 8 |
終了ページ: | 14 |
抄録: | Background: Buckwheat (BW) is the source of a life-threatening allergen. Fag e 3-specific serum IgE (sIgE) is more useful than BW-sIgE for diagnosis; however, it is unknown whether Fag e 3-sIgE can predict oral food challenge (OFC) results and anaphylaxis. This study aimed to clarify the efficacy of Fag e 3-sIgE in predicting OFC results and anaphylaxis. Methods: We conducted a retrospective review of BW- and Fag e 3-sIgE data obtained using the ImmunoCAP® assay system and fluorescent enzyme-linked immunosorbent assay from children who underwent OFC using 3, 072 mg of BW protein between July 2006 and March 2014 at Sagamihara National Hospital, Kanagawa, Japan. Results: We analyzed 60 patients aged 1.9–13.4 years (median 6.0 years); 20 (33%) showed objective symptoms upon BW OFC. The patients without symptoms had significantly lower Fag e 3-sIgE than those with non-anaphylactic (p < 0.001) and anaphylactic reactions to BW (p = 0.004). Fag e 3-sIgE was the only tested factor that significantly predicted positive OFC results (odds ratio 8.93, 95% confidence interval 3.10–25.73, p < 0.001) and OFC-induced anaphylaxis (2.67, 1.12–6.35, p = 0.027). We suggest that a threshold Fag e 3-sIgE level of 18.0 kUE/L has 95% probability of provoking a positive reaction to BW. Conclusions: Fag e 3-sIgE predicted OFC results and OFC-induced anaphylaxis. We further emphasize paying careful attention to the risk of BW OFC-induced anaphylaxis. |
著作権等: | © 2018 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
URI: | http://hdl.handle.net/2433/230950 |
DOI(出版社版): | 10.1159/000487135 |
PubMed ID: | 29635254 |
出現コレクション: | 学術雑誌掲載論文等 |
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