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Title: Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response
Other Titles: 視機性眼球運動適応時の小脳片葉における長期抑圧発現
Authors: Inoshita, Takuma  kyouindb  KAKEN_id
Hirano, Tomoo
Author's alias: 井下, 拓真
平野, 丈夫
Issue Date: 27-Mar-2018
Publisher: eLife Sciences Organisation, Ltd.
Journal title: eLife
Volume: 7
Thesis number: e36209
Abstract: Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. However, the necessity of LTD for motor learning was challenged by demonstration of normal motor learning in the LTD-defective animals. Here, we addressed possible involvement of LTD in motor learning by examining whether LTD occurs during motor learning in the wild-type mice. As a model of motor learning, adaptation of optokinetic response (OKR) was used. OKR is a type of reflex eye movement to suppress blur of visual image during animal motion. OKR shows adaptive change during continuous optokinetic stimulation, which is regulated by the cerebellar flocculus. After OKR adaptation, amplitudes of quantal excitatory postsynaptic currents at PF-PC synapses were decreased, and induction of LTD was suppressed in the flocculus. These results suggest that LTD occurs at PF-PC synapses during OKR adaptation.
Rights: © 2018, Inoshita et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
DOI(Published Version): 10.7554/eLife.36209
PubMed ID: 29582755
Appears in Collections:Journal Articles

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