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Title: Factors affecting walking ability in female patients with rheumatoid arthritis
Authors: Morita, Yugo
Ito, Hiromu
Torii, Mie  kyouindb  KAKEN_id
Hanai, Akiko
Furu, Moritoshi
Hashimoto, Motomu  kyouindb  KAKEN_id
Tanaka, Masao  kyouindb  KAKEN_id  orcid (unconfirmed)
Azukizawa, Masayuki
Arai, Hidenori
Mimori, Tsuneyo
Matsuda, Shuichi  kyouindb  KAKEN_id
Author's alias: 森田, 悠吾
伊藤, 宣
鳥井, 美江
華井, 明子
布留, 守敏
橋本, 求
田中, 真生
小豆澤, 勝幸
三森, 経世
松田, 秀一
Issue Date: 27-Mar-2018
Publisher: Public Library of Science (PLoS)
Journal title: PLOS ONE
Volume: 13
Issue: 3
Thesis number: e0195059
Abstract: Objective: To determine the factors associated with gait parameters in female patients with rheumatoid arthritis (RA). Methods: The gait analysis was performed in a large cohort of RA patients, and three basic gait parameters (step length, cadence and gait speed) were calculated. Clinical and laboratory data were also collected. Factors associated with gait parameters were analyzed using multivariable linear regression in the three models with forced entry. Then, we divided those patients with Health Assessment Questionnaire disability index (HAQ) scores ≤ 0.5 into two groups according to their gait speed that were compared to identify the characteristics of patients with a good HAQ score but poor walking ability. Results: A total of 318 female patients were analyzed. Knee extension strength had the strongest positive association with all three gait parameters (P < 0.0001), while methotrexate use was also positively associated with all three gait parameters (step length: P < 0.05, cadence: P < 0.05 in model 1 and 2; P < 0.01 in model 3, gait speed: P < 0.01). The disease activity score was negatively associated with step length and gait speed (step length, gait speed: P < 0.01 in model 1 and 2; P < 0.05 in model 3). 26% of patients with good HAQ scores showed slow gait speed. Patients with good HAQ scores and slow gait speed had higher disease activity scores (P < 0.05) and lower knee extension strength (P < 0.0001) than those with good HAQ scores and normal gait speed. Conclusions: High knee extension strength, low disease activity and administration of methotrexate were strongly associated with good walking ability in female patients with RA. And, even if patients showed good HAQ scores, about quarter of those patients had poor walking ability, and they showed higher disease activity, lower knee extension strength, compared to the patients with normal gait speed.
Rights: © 2018 Morita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0195059
PubMed ID: 29584787
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