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タイトル: | Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer |
著者: | Vu, Binh Thanh Shahin, Sophia Allaf Croissant, Jonas Fatieiev, Yevhen Matsumoto, Kotaro Le-Hoang Doan, Tan Yik, Tammy Simargi, Shirleen Conteras, Altagracia Ratliff, Laura Jimenez, Chiara Mauriello Raehm, Laurence Khashab, Niveen Durand, Jean-Olivier Glackin, Carlotta Tamanoi, Fuyuhiko https://orcid.org/0000-0002-4220-6408 (unconfirmed) |
著者名の別形: | 玉野井, 冬彦 |
キーワード: | Cancer Targeted therapies |
発行日: | 4-Jun-2018 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 8 |
論文番号: | 8524 |
抄録: | New therapy development is critically needed for ovarian cancer. We used the chicken egg CAM assay to evaluate efficacy of anticancer drug delivery using recently developed biodegradable PMO (periodic mesoporous organosilica) nanoparticles. Human ovarian cancer cells were transplanted onto the CAM membrane of fertilized eggs, resulting in rapid tumor formation. The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. PMO nanoparticles loaded with doxorubicin were injected intravenously into the chicken egg resulting in elimination of the tumor. No significant damage to various organs in the chicken embryo occurred. In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered. The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulation of the nanoparticles. Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. |
記述: | がんの個別化医療を可能にする患者癌由来の鶏卵モデル. 京都大学プレスリリース. 2018-06-06. |
著作権等: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/231401 |
DOI(出版社版): | 10.1038/s41598-018-25573-8 |
PubMed ID: | 29867159 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2018-06-06 |
出現コレクション: | 学術雑誌掲載論文等 |
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