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タイトル: Controlling Cell Fate Specification System by Key Genes Determined from Network Structure
著者: Kobayashi, Kenji
Maeda, Kazuki
Tokuoka, Miki
Mochizuki, Atsushi
Satou, Yutaka  kyouindb  KAKEN_id
著者名の別形: 小林, 健司
前田, 一貴
徳岡, 三紀
望月, 敦史
佐藤, ゆたか
キーワード: Bioinformatics
Mathematical Biosciences
Complex System Biology
Experimental Models in Systems Biology
発行日: 29-Jun-2018
出版者: Elsevier BV
誌名: iScience
巻: 4
開始ページ: 281
終了ページ: 293
抄録: Network structures describing regulation between biomolecules have been determined in many biological systems. Dynamics of molecular activities based on such networks are considered to be the origin of many biological functions. Recently, it has been proved mathematically that key nodes for controlling dynamics in networks are identified from network structure alone. Here, we applied this theory to a gene regulatory network for the cell fate specification of seven tissues in the ascidian embryo and found that this network, which consisted of 92 factors, had five key molecules. By controlling the activities of these key molecules, the specific gene expression of six of seven tissues observed in the embryo was successfully reproduced. Since this method is applicable to all nonlinear dynamic systems, we propose this method as a tool for controlling gene regulatory networks and reprogramming cell fates.
記述: 遺伝子ネットワークを制御してさまざまな種類の細胞を作り出す --数学的理論に基づく細胞運命の制御に成功--. 京都大学プレスリリース. 2018-06-13.
著作権等: © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/231941
DOI(出版社版): 10.1016/j.isci.2018.05.004
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2018/180608_1.html
出現コレクション:学術雑誌掲載論文等

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