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タイトル: Estimation of chimpanzee age based on DNA methylation
著者: Ito, Hideyuki
Udono, Toshifumi
Hirata, Satoshi
Inoue-Murayama, Miho
著者名の別形: 伊藤, 英之
鵜殿, 俊史
平田, 聡
村山, 美穂
キーワード: Ageing
DNA methylation
Methylation analysis
発行日: 3-Jul-2018
出版者: Springer Nature
誌名: Scientific Reports
巻: 8
論文番号: 9998
抄録: In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wild animals. In the present study, a chimpanzee (Pan troglodytes) age prediction model was developed based on the ELOVL2, CCDC102B, and ZNF423 genes that may also have application in human age prediction. Pyrosequencing was used to measure methylation in 20 chimpanzee blood samples and correlation between age and methylation status was calculated. Age and methylation of sites in ELOVL2 and CCDC102B were significantly correlated and an age prediction model was created using these genes. In the regression equation using only ELOVL2, the highest correlation coefficient was 0.741, with a mean absolute deviation (MAD) of 5.41, compared with the combination of ELOVL2 and CCDC102B, where the highest correlation coefficient was 0.742 and the MAD was 5.41. Although larger MADs were observed in chimpanzees than in humans based on these genes, the results indicate the feasibility of estimating chimpanzee age using DNA methylation, and can have implications in understanding the ecology of chimpanzees and chimpanzee conservation.
記述: DNAを用いたチンパンジーの年齢推定に成功 --野生動物の生態解明研究に画期的な進歩--. 京都大学プレスリリース. 2018-07-09.
著作権等: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/232615
DOI(出版社版): 10.1038/s41598-018-28318-9
PubMed ID: 29968770
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2018/180703_3.html
出現コレクション:学術雑誌掲載論文等

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