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j.celrep.2018.06.013.pdf | 6.2 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Kawabata Galbraith, Kelly | en |
dc.contributor.author | Fujishima, Kazuto | en |
dc.contributor.author | Mizuno, Hiroaki | en |
dc.contributor.author | Lee, Sung-Jin | en |
dc.contributor.author | Uemura, Takeshi | en |
dc.contributor.author | Sakimura, Kenji | en |
dc.contributor.author | Mishina, Masayoshi | en |
dc.contributor.author | Watanabe, Naoki | en |
dc.contributor.author | Kengaku, Mineko | en |
dc.contributor.alternative | 川端 Galbraith, ケリー | ja |
dc.contributor.alternative | 藤島, 和人 | ja |
dc.contributor.alternative | 水野, 裕昭 | ja |
dc.contributor.alternative | 李, 聖真 | ja |
dc.contributor.alternative | 植村, 健 | ja |
dc.contributor.alternative | 崎村, 建司 | ja |
dc.contributor.alternative | 三品, 昌美 | ja |
dc.contributor.alternative | 渡邊, 直樹 | ja |
dc.contributor.alternative | 見学, 美根子 | ja |
dc.date.accessioned | 2018-07-17T02:16:15Z | - |
dc.date.available | 2018-07-17T02:16:15Z | - |
dc.date.issued | 2018-07-03 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2433/232641 | - |
dc.description | アクチン繊維のわずかな偏りが脳神経細胞の形を決めることを発見しました. 京都大学プレスリリース. 2018-07-17. | ja |
dc.description.abstract | Dendritic filopodia of developing neurons function as environmental sensors, regulating the spatial organization of dendrites and proper targeting to presynaptic partners. Dendritic filopodia morphology is determined by the balance of F-actin assembled via two major nucleating pathways, the ARP2/3 complex and formins. The inverse-BAR protein MTSS1 is highly expressed in Purkinje cells (PCs) and has been shown to upregulate ARP2/3 activity. PCs in MTSS1 conditional knockout mice showed dendrite hypoplasia due to excessive contact-induced retraction during development. This phenotype was concomitant with elongated dendritic filopodia and was phenocopied by overactivation of the actin nucleator formin DAAM1 localized in the tips of PC dendritic protrusions. Cell biology assays including single-molecule speckle microscopy demonstrated that MTSS1’s C terminus binds to DAAM1 and paused DAAM1-mediated F-actin polymerization. Thus, MTSS1 plays a dual role as a formin inhibitor and ARP2/3 activator in dendritic filopodia, determining final neuronal morphology. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.subject | dendrite | en |
dc.subject | actin | en |
dc.subject | Purkinje cell | en |
dc.subject | neuron | en |
dc.subject | filopodia | en |
dc.subject | spine | en |
dc.subject | ARP2/3 | en |
dc.subject | formin | en |
dc.subject | MTSS1 | en |
dc.subject | DAAM1 | en |
dc.title | MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Reports | en |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 95 | - |
dc.identifier.epage | 106.e9 | - |
dc.relation.doi | 10.1016/j.celrep.2018.06.013 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 29972794 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2018-07-17 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 16H06484 | - |
datacite.awardNumber | 16H04676 | - |
datacite.awardNumber | 16K18363 | - |
datacite.awardNumber | 16J11619 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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