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Title: Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under Chronic Jet Lag
Authors: Yamaguchi, Yoshiaki  kyouindb  KAKEN_id  orcid (unconfirmed)
Okamura, Hitoshi
Author's alias: 山口, 賀章
岡村, 均
Keywords: Human Activity in Medical Context
Behavioral Neuroscience
Issue Date: 27-Jul-2018
Publisher: Elsevier BV
Journal title: iScience
Volume: 5
Start page: 118
End page: 122
Abstract: Chronic jet lag, a model of shiftwork, increases mortality in aged mice. One potential reason for this association is that the chronic desynchronization between the internal clock phase and the environmental light/dark (LD) cycle might increase the mortality rate. However, this hypothesis has not been examined because of the lack of an appropriate animal model to prove this speculation. Here, we found that rapidly entrainable vasopressin receptor V1a–/–V1b–/– mice showed lower mortality under a chronic jet lag condition. Moreover, we found that pharmacological inactivation of V1a and V1b signaling decreased mortality even in aged wild-type mice, thus providing a potential pharmaceutical intervention for shiftwork-related health problems.
Description: 慢性時差環境下での老齢マウスの生存率改善に成功 --シフトワーカーの病態への創薬に期待--. 京都大学プレスリリース. 2018-07-20.
Rights: © 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (
DOI(Published Version): 10.1016/j.isci.2018.06.008
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