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タイトル: | Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain |
著者: | Fujiyama, Tomoyuki Miyashita, Satoshi Tsuneoka, Yousuke Kanemaru, Kazumasa Kakizaki, Miyo Kanno, Satomi Ishikawa, Yukiko Yamashita, Mariko Owa, Tomoo Nagaoka, Mai Kawaguchi, Yoshiya Yanagawa, Yuchio Magnuson, Mark A. Muratani, Masafumi Shibuya, Akira Nabeshima, Yo-ichi Yanagisawa, Masashi Funato, Hiromasa Hoshino, Mikio |
著者名の別形: | 川口, 義弥 |
キーワード: | sexual differentiation sexual behavior hypothalamus Ptf1a kisspeptin central nervous system |
発行日: | 3-Jul-2018 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 24 |
号: | 1 |
開始ページ: | 79 |
終了ページ: | 94 |
抄録: | The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied. We found that Ptf1a is expressed in certain neuroepithelial cells and immature neurons around the third ventricle that give rise to various neurons in several hypothalamic nuclei. We show that conditional Ptf1a-deficient mice (Ptf1a cKO) exhibit abnormalities in sex-biased behaviors and reproductive organs in both sexes. Gonadal hormone administration to gonadectomized animals revealed that the abnormal behavior is caused by disorganized sexual development of the knockout brain. Accordingly, expression of sex-biased genes was severely altered in the cKO hypothalamus. In particular, Kiss1, important for sexual differentiation of the brain, was drastically reduced in the cKO hypothalamus, which may contribute to the observed phenotypes in the Ptf1a cKO. These findings suggest that forebrain Ptf1a is one of the earliest regulators for sexual differentiation of the brain. |
著作権等: | © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/232699 |
DOI(出版社版): | 10.1016/j.celrep.2018.06.010 |
PubMed ID: | 29972772 |
出現コレクション: | 学術雑誌掲載論文等 |
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