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Title: Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium
Authors: Mizumoto, Ayaka
Ohashi, Shinya  kyouindb  KAKEN_id
Hirohashi, Kenshiro
Amanuma, Yusuke
Matsuda, Tomonari  kyouindb  KAKEN_id
Muto, Manabu  kyouindb  KAKEN_id
Author's alias: 水本, 綾佳
大橋, 真也
廣橋, 研志郎
天沼, 裕介
松田, 知成
武藤, 学
Keywords: acetaldehyde
DNA adduct
esophageal squamous cell carcinoma
head and neck squamous cell carcinoma
DNA damage
cancer development
DNA repair pathway
Issue Date: 10-Sep-2017
Publisher: MDPI AG
Journal title: International Journal of Molecular Sciences
Volume: 18
Issue: 9
Thesis number: 1943
Abstract: Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA, including DNA adducts, single- and/or double-strand breaks (DSBs), point mutations, sister chromatid exchanges (SCEs), and DNA–DNA cross-links. Among these, DNA adducts such as N2-ethylidene-2′-deoxyguanosine, N2-ethyl-2′-deoxyguanosine, N2-propano-2′-deoxyguanosine, and N2-etheno-2′-deoxyguanosine are central to acetaldehyde-mediated DNA damage because they are associated with the induction of DNA mutations, DNA–DNA cross-links, DSBs, and SCEs. Acetaldehyde is produced endogenously by alcohol metabolism and is catalyzed by aldehyde dehydrogenase 2 (ALDH2). Alcohol consumption increases blood and salivary acetaldehyde levels, especially in individuals with ALDH2 polymorphisms, which are highly associated with the risk of squamous cell carcinomas in the upper aerodigestive tract. Based on extensive epidemiological evidence, the International Agency for Research on Cancer defined acetaldehyde associated with the consumption of alcoholic beverages as a “group 1 carcinogen” (definite carcinogen) for the esophagus and/or head and neck. In this article, we review recent advances from studies of acetaldehyde-mediated carcinogenesis in the squamous epithelium, focusing especially on acetaldehyde-mediated DNA adducts. We also give attention to research on acetaldehyde-mediated DNA repair pathways such as the Fanconi anemia pathway and refer to our studies on the prevention of acetaldehyde-mediated DNA damage.
Rights: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
URI: http://hdl.handle.net/2433/233626
DOI(Published Version): 10.3390/ijms18091943
PubMed ID: 28891965
Appears in Collections:Journal Articles

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