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タイトル: Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes
著者: Sunagawa, Yoichi
Funamoto, Masafumi
Sono, Shogo
Shimizu, Kana
Shimizu, Satoshi
Genpei, Mai
Miyazaki, Yusuke
Katanasaka, Yasufumi
Morimoto, Eriko
Ueno, Morio
Komiyama, Maki
Kakeya, Hideaki  kyouindb  KAKEN_id
Wada, Hiromichi
Hasegawa, Koji
Morimoto, Tatsuya
著者名の別形: 掛谷, 秀昭
キーワード: Curcumin
Demethoxycurcumin
Bisdemethoxycurcumin
p300
Cardiomyocyte hypertrophy
発行日: Apr-2018
出版者: Elsevier BV
誌名: Journal of Pharmacological Sciences
巻: 136
号: 4
開始ページ: 212
終了ページ: 217
抄録: The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy.
Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure–activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy.
著作権等: © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/233908
DOI(出版社版): 10.1016/j.jphs.2017.12.013
PubMed ID: 29602708
出現コレクション:学術雑誌掲載論文等

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