ダウンロード数: 199
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.jphs.2017.12.013.pdf | 722.67 kB | Adobe PDF | 見る/開く |
タイトル: | Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes |
著者: | Sunagawa, Yoichi Funamoto, Masafumi Sono, Shogo Shimizu, Kana Shimizu, Satoshi Genpei, Mai Miyazaki, Yusuke Katanasaka, Yasufumi Morimoto, Eriko Ueno, Morio Komiyama, Maki Kakeya, Hideaki https://orcid.org/0000-0002-4293-7331 (unconfirmed) Wada, Hiromichi Hasegawa, Koji Morimoto, Tatsuya |
著者名の別形: | 掛谷, 秀昭 |
キーワード: | Curcumin Demethoxycurcumin Bisdemethoxycurcumin p300 Cardiomyocyte hypertrophy |
発行日: | Apr-2018 |
出版者: | Elsevier BV |
誌名: | Journal of Pharmacological Sciences |
巻: | 136 |
号: | 4 |
開始ページ: | 212 |
終了ページ: | 217 |
抄録: | The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy. Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure–activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy. |
著作権等: | © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/233908 |
DOI(出版社版): | 10.1016/j.jphs.2017.12.013 |
PubMed ID: | 29602708 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。