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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| nano8020079.pdf | 2.1 MB | Adobe PDF | 見る/開く |
| タイトル: | Polymeric micelle of a3 b-type lactosome as a vehicle for targeting meningeal dissemination |
| 著者: | Kurihara, Kensuke Ueda, Motoki Hara, Isao Ozeki, Eiichi Togashi, Kaori Kimura, Shunsaku   |
| 著者名の別形: | 富樫, かおり 木村, 俊作 |
| キーワード: | Bone metastasis Meningeal dissemination Molecular imaging Polymeric micelle SPECT |
| 発行日: | 1-Feb-2018 |
| 出版者: | MDPI AG |
| 誌名: | Nanomaterials |
| 巻: | 8 |
| 号: | 2 |
| 論文番号: | 79 |
| 抄録: | Polymeric micelle of the A₃B-type lactosome comprising (poly(sarcosine))₃-b-poly(l-lactic acid) was labeled with ¹¹¹In. The ¹¹¹In-labeled A₃B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by ¹¹¹In-labeled A₃B-type lactosome, which was superior to ²⁰¹TlCl in regard of the imaging contrast. The ¹¹¹In-labeled A₃B-type lactosome was also potential in imaging selectively of bone metastasis at mandible, whilst a nonspecific imaging of the whole bone was obtained by the SPECT imaging using ⁹⁹mTc-HMDP. The polymeric micelle of the A₃B-type lactosome was therefore found to be effective as a vehicle of ¹¹¹In to be targeted to meningeal dissemination and bone metastasis. |
| 著作権等: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). |
| URI: | http://hdl.handle.net/2433/233952 |
| DOI(出版社版): | 10.3390/nano8020079 |
| PubMed ID: | 29385027 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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