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| s41598-018-27009-9.pdf | 2.71 MB | Adobe PDF | 見る/開く |
| タイトル: | Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo |
| 著者: | Nakazeki, Fumiko Nishiga, Masataka Horie, Takahiro   Nishi, Hitoo Nakashima, Yasuhiro Baba, Osamu Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Ide, Yuya Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Sowa, Naoya Yoshida, Shigeo Conway, Simon J. Yanagita, Motoko Kimura, Takeshi Ono, Koh |
| 著者名の別形: | 西賀, 雅隆 堀江, 貴裕 西, 仁勇 中島, 康弘 馬場, 理 桑原, 康秀 西野, 共達 中尾, 哲史 井手, 裕也 小山, 智史 柳田, 素子 木村, 剛 尾野, 亘 |
| 発行日: | 4-Jul-2018 |
| 出版者: | Springer Nature |
| 誌名: | Scientific reports |
| 巻: | 8 |
| 論文番号: | 8553 |
| 抄録: | Recent evidence suggests that the accumulation of macrophages as a result of obesity-induced adipose tissue hypoxia is crucial for the regulation of tissue fibrosis, but the molecular mechanisms underlying adipose tissue fibrosis are still unknown. In this study, we revealed that periostin (Postn) is produced at extraordinary levels by adipose tissue after feeding with a high-fat diet (HFD). Postn was secreted at least from macrophages in visceral adipose tissue during the development of obesity, possibly due to hypoxia. Postn⁻/⁻ mice had lower levels of crown-like structure formation and fibrosis in adipose tissue and were protected from liver steatosis. These mice also showed amelioration in systemic insulin resistance compared with HFD-fed WT littermates. Mice deficient in Postn in their hematopoietic compartment also had lower levels of inflammation in adipose tissue, in parallel with a reduction in ectopic lipid accumulation compared with the controls. Our data indicated that the regulation of Postn in visceral fat could be beneficial for the maintenance of healthy adipose tissue in obesity. |
| 著作権等: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/234184 |
| DOI(出版社版): | 10.1038/s41598-018-27009-9 |
| PubMed ID: | 29867212 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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