このアイテムのアクセス数: 23

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
s41467-018-06187-0.pdf1.93 MBAdobe PDF見る/開く
タイトル: Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
著者: Yoshitomi, Hiroyuki
Kobayashi, Shio
Miyagawa-Hayashino, Aya
Okahata, Akinori
Doi, Kohei
Nishitani, Kohei  kyouindb  KAKEN_id
Murata, Koichi
Ito, Hiromu
Tsuruyama, Tatsuaki
Haga, Hironori
Matsuda, Shuichi
Toguchida, Junya
著者名の別形: 吉富, 啓之
小林, 志緒
宮川, 文
西谷, 江平
村田, 浩一
伊藤, 宣
鶴山, 竜昭
羽賀, 博典
松田, 秀一
戸口田, 淳也
キーワード: CD4-positive T cells
Chemokines
Chronic inflammation
Rheumatoid arthritis
発行日: 19-Sep-2018
出版者: Springer Nature America, Inc
誌名: Nature Communications
巻: 9
論文番号: 3762
抄録: In human inflammatory sites, PD-1hiCXCR5−CD4+ T cells are involved in the formation of ectopic lymphoid-like structures (ELSs) by the secretion of chemokine CXCL13, but how the transcription of CXCL13 is regulated in CD4+ T cells is still unclear. Here we show that Sox4 is a key transcription factor for CXCL13 production in human CD4+ T cells under inflammatory conditions. In vitro TGF-β+, IL-2-neutralizing culture conditions give rise to PD-1hiCXCR5−CD4+ T cells that preferentially express CXCL13, and transcriptome analysis and lentiviral overexpression indicate Sox4 association with the CXCL13 transcription. In vivo, Sox4 is significantly upregulated in synovial CD4+ T cells, when compared with blood CD4+ T cells, from patients with rheumatoid arthritis (RA), and further correlates with ELS formation in RA synovium. Overall, our studies suggest that Sox4 contributes to CXCL13 production and ELS formation at inflammatory sites in humans.
記述: 関節リウマチの病態に関わる転写因子を同定 --炎症環境におけるT細胞の新たな機能解明に期待--. 京都大学プレスリリース. 2018-09-25.
著作権等: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/234599
DOI(出版社版): 10.1038/s41467-018-06187-0
PubMed ID: 30232328
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2018/180919_1.html
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。