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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41598-018-19995-7.pdf | 2.21 MB | Adobe PDF | 見る/開く |
| タイトル: | Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing |
| 著者: | Okada, Kazuhisa Wongboot, Warawan Chantaroj, Siriporn Natakuathung, Wirongrong Roobthaisong, Amonrattana Kamjumphol, Watcharaporn Maruyama, Fumito   https://orcid.org/0000-0003-2347-616X (unconfirmed)Takemura, Taichiro Nakagawa, Ichiro  https://orcid.org/0000-0001-6552-1702 (unconfirmed)Ohnishi, Makoto Hamada, Shigeyuki |
| 著者名の別形: | 丸山, 史人 中川, 一路 |
| 発行日: | 26-Jan-2018 |
| 出版者: | Springer Nature |
| 誌名: | Scientific Reports |
| 巻: | 8 |
| 論文番号: | 1631 |
| 抄録: | Vibrio cholerae inhabits aquatic environments worldwide and has over 200 recognized serogroups classified by O-polysaccharide specificity. Here, we report that V. cholerae selects either of two genetic traits during their evolution. Sequencing of the specific gene locus MS6_A0927 revealed that 339 of 341 strains of V. cholerae and closely related Vibrio species originating from 34 countries over a century carried either metY (M) (~1, 269 bp) or luxR-hchA (LH) (~1, 600 bp) genes, and consequently those vibrios were separated into two clusters, M (45.4%) and LH (54.6%). Only two strains contained both M and LH in the same locus. Moreover, extensive polymorphisms in those genes were detected in M and LH with 79 and 46 sequence variations, respectively. V. cholerae O1 strains isolated from cholera outbreaks worldwide, and some non-O1 strains evolving from O1 via exchange of genes encoding cell surface polysaccharides possessed LH alleles. Analysis of polymorphisms in the gene locus implicated a high degree of genetic diversity and identical subpopulations among the V. cholerae species. |
| 著作権等: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/235196 |
| DOI(出版社版): | 10.1038/s41598-018-19995-7 |
| PubMed ID: | 29374205 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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