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Title: Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method
Authors: Kuwabara, Junko
Kuwahara, Koichiro
Kuwabara, Yoshihiro
Yasuno, Shinji
Nakagawa, Yasuaki  kyouindb  KAKEN_id
Ueshima, Kenji  kyouindb  KAKEN_id
Kimura, Takeshi  kyouindb  KAKEN_id
Author's alias: 桒原, 佳宏
中川, 靖章
上嶋, 健治
木村, 剛
Issue Date: 5-Nov-2018
Publisher: Public Library of Science (PLoS)
Journal title: PLOS ONE
Volume: 13
Thesis number: e0206945
Abstract: [Background] The blood pressure (BP) variability (BPV) is a predictor of cardiovascular disease, independently of the BP itself. In addition, visceral fat accumulation can trigger atherosclerotic disease through various mechanisms. [Methods and results] We examined the association between fat accumulation and day-to-day BPV in 61 adult hypertensive patients. Visceral fat area (VFA) was measured using the dual bioelectrical impedance analysis method. Participants were divided into three groups based on VFA. The standard deviation (SD) in home systolic BP (SBP) for 7 consecutive days was significantly lower in the high VFA tertile (low VFA, 8.40±4.15 mmHg; intermediate VFA, 8.47±2.80 mmHg; and high VFA, 5.84±2.37 mmHg, p of One-way ANOVA = 0.017, p for trend = 0.0126). A similar association was observed between the coefficient of variance (CV) of home SBP and the VFA tertile. Multiple-regression analysis adjusted for age, sex, antihypertensive drug, diabetes, habitual drinking, and SBP level also showed a significant association between the VFA tertile and the SD or CV of home SBP. The adjusted coefficient of regression for the SD of home SBP was -3.28 (95%CI: -5.60 to -0.97, p = 0.008) and the CV of home SBP was -2.51 (95%CI: -4.31 to -0.71, p = 0.008) for the highest VFA tertile as compared to the lowest VFA tertile. [Conclusions] These results show for the first time negative correlation between VFA and day-to-day BPV. The degree of obesity should be taken into account when evaluating the value of BPV.
Rights: © 2018 Kuwabara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/235205
DOI(Published Version): 10.1371/journal.pone.0206945
PubMed ID: 30395594
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