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dc.contributor.authorKuwabara, Junkoen
dc.contributor.authorKuwahara, Koichiroen
dc.contributor.authorKuwabara, Yoshihiroen
dc.contributor.authorYasuno, Shinjien
dc.contributor.authorNakagawa, Yasuakien
dc.contributor.authorUeshima, Kenjien
dc.contributor.authorKimura, Takeshien
dc.contributor.alternative桒原, 佳宏ja
dc.contributor.alternative中川, 靖章ja
dc.contributor.alternative上嶋, 健治ja
dc.contributor.alternative木村, 剛ja
dc.date.accessioned2018-11-19T01:57:10Z-
dc.date.available2018-11-19T01:57:10Z-
dc.date.issued2018-11-05-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2433/235205-
dc.description.abstract[Background] The blood pressure (BP) variability (BPV) is a predictor of cardiovascular disease, independently of the BP itself. In addition, visceral fat accumulation can trigger atherosclerotic disease through various mechanisms. [Methods and results] We examined the association between fat accumulation and day-to-day BPV in 61 adult hypertensive patients. Visceral fat area (VFA) was measured using the dual bioelectrical impedance analysis method. Participants were divided into three groups based on VFA. The standard deviation (SD) in home systolic BP (SBP) for 7 consecutive days was significantly lower in the high VFA tertile (low VFA, 8.40±4.15 mmHg; intermediate VFA, 8.47±2.80 mmHg; and high VFA, 5.84±2.37 mmHg, p of One-way ANOVA = 0.017, p for trend = 0.0126). A similar association was observed between the coefficient of variance (CV) of home SBP and the VFA tertile. Multiple-regression analysis adjusted for age, sex, antihypertensive drug, diabetes, habitual drinking, and SBP level also showed a significant association between the VFA tertile and the SD or CV of home SBP. The adjusted coefficient of regression for the SD of home SBP was -3.28 (95%CI: -5.60 to -0.97, p = 0.008) and the CV of home SBP was -2.51 (95%CI: -4.31 to -0.71, p = 0.008) for the highest VFA tertile as compared to the lowest VFA tertile. [Conclusions] These results show for the first time negative correlation between VFA and day-to-day BPV. The degree of obesity should be taken into account when evaluating the value of BPV.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)en
dc.rights© 2018 Kuwabara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.titleCross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance methoden
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitlePLOS ONEen
dc.identifier.volume13-
dc.relation.doi10.1371/journal.pone.0206945-
dc.textversionpublisher-
dc.identifier.artnume0206945-
dc.addressDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicineen
dc.addressDepartment of Cardiovascular Medicine, Shinshu University School of Medicineen
dc.addressCenter for Accessing Early Promising Treatment, Kyoto University Hospitalen
dc.addressDepartment of EBM Research, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospitalen
dc.addressDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicineen
dc.addressCenter for Accessing Early Promising Treatment, Kyoto University Hospitalen
dc.addressDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicineen
dc.identifier.pmid30395594-
dcterms.accessRightsopen access-
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