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Title: Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis
Authors: Nakagawa, Shunsaku  kyouindb  KAKEN_id
Nakaishi, Mayumi
Hashimoto, Motomu  kyouindb  KAKEN_id
Ito, Hiromu
Yamamoto, Wataru
Nakashima, Ran
Tanaka, Masao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8942-2933 (unconfirmed)
Fujii, Takao
Omura, Tomohiro
Imai, Satoshi  kyouindb  KAKEN_id
Nakagawa, Takayuki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1890-0843 (unconfirmed)
Yonezawa, Atsushi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8057-6768 (unconfirmed)
Imai, Hirohisa
Mimori, Tsuneyo
Matsubara, Kazuo
Author's alias: 中川, 俊作
橋本, 求
伊藤, 宣
中嶋, 蘭
田中, 真生
藤井, 隆夫
大村, 友博
今井, 哲司
中川, 貴之
米澤, 淳
三森, 経世
松原, 和夫
Issue Date: 2-Nov-2018
Publisher: Public Library of Science (PLoS)
Journal title: PLOS ONE
Volume: 13
Thesis number: e0206943
Abstract: For the optimum efficacy of disease-modifying anti-rheumatic drugs (DMARDs), patients need to be adherent to their medication regimen. To clarify the effects of medication adherence on disease activity in Japanese patients with rheumatoid arthritis (RA), we conducted a cohort study in patients with various stages of RA. Patients were enrolled from the Kyoto University RA Management Alliance cohort, and followed up prospectively for 12 months. In this study, a total of 475 patients were analyzed and divided into 9 groups according to their medication adherence and the RA disease duration. The primary outcomes were based on the rate of a disease flare. The secondary outcomes were the changes in disease activity score using 28 joints (DAS28-ESR), simplified disease activity index (SDAI) and physical disability by health assessment questionnaire-disability index (HAQ). The changes in DAS28-ESR, HAQ, and the risk of disease flare in the highly adherent patients were significantly lower than those of the less adherent patients among the groups with RA ≤ 4.6 years but not those among the other groups. Taken together, this study identified a significant association between medication adherence and the disease flare during early-stage RA or short disease duration. These results emphasize the need to pay more attention to medication adherence in preventing the disease progression of RA.
Rights: © 2018 Nakagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/235206
DOI(Published Version): 10.1371/journal.pone.0206943
PubMed ID: 30388179
Appears in Collections:Journal Articles

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