Downloads: 96

Files in This Item:
File Description SizeFormat 
s41598-018-35419-y.pdf2.87 MBAdobe PDFView/Open
Title: Evaluation of Structure-Function Relationships in Longitudinal Changes of Glaucoma using the Spectralis OCT Follow-Up Mode
Authors: Suda, Kenji  kyouindb  KAKEN_id  orcid (unconfirmed)
Akagi, Tadamichi
Nakanishi, Hideo
Noma, Hisashi
Ikeda, Hanako Ohashi
Kameda, Takanori  kyouindb  KAKEN_id
Hasegawa, Tomoko
Tsujikawa, Akitaka  kyouindb  KAKEN_id
Author's alias: 須田, 謙史
赤木, 忠道
中西, 秀雄
池田, 華子
亀田, 隆範
長谷川, 智子
辻川, 明孝
Issue Date: 21-Nov-2018
Publisher: Springer Nature America, Inc
Journal title: Scientific reports
Volume: 8
Thesis number: 17158
Abstract: The detection of glaucoma progression is an essential part of glaucoma management. Subjectivity of standard automated perimetry (SAP) prevents the accurate evaluation of progression, thus the detection of structural changes by optical coherence tomography (OCT) is attracting attention. Despite its objectivity, there is controversy about the appropriateness of the use of OCT, because many previous studies have indicated OCT results may not reflect the deterioration of visual field. A reason for this dissociation may be the test-retest variability of OCT, a major cause of which is misplacement of the measurement location. Recent advantages of spectral-domain OCT (SD-OCT), especially Spectralis OCT with an eye-tracking system (follow-up mode) enable measurement at approximately the same location as previous examinations. In addition to utilizing Spectralis follow-up mode, we introduced structure-function relationship map and nonlinear relationship between SAP and OCT results in considering structure-function relationship in longitudinal changes. The introduction of these two ideas in our study population improved the correlation between the SAP and OCT (R = 0.589 at most). The results of this study support the practical use of OCT in glaucoma progression but also stress the importance of focus on the corresponding focal changes and the consideration of disease severity.
Rights: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41598-018-35419-y
PubMed ID: 30464292
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks

Export Format: 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.