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Title: Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants
Authors: Higo, Asuka
Kawashima, Tomokazu
Borg, Michael
Zhao, Mingmin
López-Vidriero, Irene
Sakayama, Hidetoshi
Montgomery, Sean A.
Sekimoto, Hiroyuki
Hackenberg, Dieter
Shimamura, Masaki
Nishiyama, Tomoaki
Sakakibara, Keiko
Tomita, Yuki
Togawa, Taisuke
Kunimoto, Kan
Osakabe, Akihisa
Suzuki, Yutaka
Yamato, Katsuyuki T.
Ishizaki, Kimitsune
Nishihama, Ryuichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Kohchi, Takayuki
Franco-Zorrilla, José M.
Twell, David
Berger, Frédéric
Araki, Takashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 肥後, あすか
河島, 友和
坂山, 英俊
関本, 弘之
嶋村, 正樹
西山, 智明
榊原, 恵子
冨田, 由妃
十川, 太輔
國本, 完
越阪部, 晃永
鈴木, 穣
大和, 勝幸
石崎, 公庸
西浜, 竜一
河内, 孝之
荒木, 崇
Keywords: Differentiation
Evolutionary developmental biology
Plant reproduction
Issue Date: 11-Dec-2018
Publisher: Springer Nature
Journal title: Nature Communications
Volume: 9
Thesis number: 5283
Abstract: Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. This event led to the differentiation of motile sperm. After neo-functionalization, DUO1 acquired sperm lineage-specific expression in the common ancestor of land plants. Subsequently the downstream network of DUO1 was rewired leading to sperm with distinct morphologies. Conjugating green algae, a sister group of land plants, accumulated mutations in the DNA-binding domain of DUO1 and lost sperm differentiation. Our findings suggest that the emergence of DUO1 was the defining event in the evolution of sperm differentiation and the varied modes of sexual reproduction in the land plant lineage.
Description: 植物の多様な精子の形成の進化的起源を解明 --7億年前のDUO1遺伝子獲得が植物の精子形成に関わる--. 京都大学プレスリリース. 2018-12-13.
Rights: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41467-018-07728-3
PubMed ID: 30538242
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