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Title: Capturing microscopic features of bone remodeling into a macroscopic model based on biological rationales of bone adaptation
Authors: Kim, Kwan, Young
Kameo, Yoshitaka  kyouindb  KAKEN_id
Tanaka, Sakae
Adachi, Taiji  kyouindb  KAKEN_id
Author's alias: 金, 英寛
亀尾, 佳貴
安達, 泰治
Keywords: Bone adaptation
Wolff’s law
Biological rationale
Model reduction
Multiscale biomechanics
Issue Date: Oct-2017
Publisher: Springer Nature
Journal title: Biomechanics and Modeling in Mechanobiology
Volume: 16
Issue: 5
Start page: 1697
End page: 1708
Abstract: To understand Wolff’s law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account. The proposed models were categorized into two groups according to whether the remodeling equilibrium state was defined globally or locally, i.e., the global or local uniformity models. Each remodeling stimulus in the proposed models was quantitatively evaluated through image-based finite element analyses of a swine cancellous bone, according to two introduced criteria associated with the trabecular volume and orientation at remodeling equilibrium based on biological rationales. The evaluation suggested that nonuniformity of the mean stress gradient in the local uniformity model, one of the proposed stimuli, has high validity. Furthermore, the adaptive potential of each stimulus was discussed based on spatial distribution of a remodeling stimulus on the trabecular surface. The theoretical consideration of a remodeling stimulus based on biological rationales of bone adaptation would contribute to the establishment of a clinically applicable and reliable simulation model of bone remodeling.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Biomechanics and Modeling in Mechanobiology. The final authenticated version is available online at:
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1007/s10237-017-0914-6
PubMed ID: 28523374
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