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タイトル: | Toward the development of true “off-the-shelf” synthetic T-cell immunotherapy |
著者: | Iriguchi, Shoichi Kaneko, Shin |
著者名の別形: | 入口, 翔一 金子, 新 |
キーワード: | antigen specificity iPS cell regenerative immunotherapy T cell differentiation T cell rejuvenation |
発行日: | Jan-2019 |
出版者: | Blackwell Publishing Ltd |
誌名: | Cancer Science |
巻: | 110 |
号: | 1 |
開始ページ: | 16 |
終了ページ: | 22 |
抄録: | Recent outstanding clinical results produced by engineered T cells, including chimeric antigen receptors, have already facilitated further research that broadens their applicability. One such direction is to explore new T cell sources for allogeneic “off‐the‐shelf” adoptive immunotherapy. Human pluripotent stem cells could serve as an alternative cell source for this purpose due to their unique features of infinite propagation ability and pluripotency. Here, we describe the current state of engineered T cell transfer with the focus on cell manufacturing processes and the potentials and challenges of induced pluripotent stem cell‐derived T cells as a starting material to construct off‐the‐shelf T‐cell banks. |
著作権等: | © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/235946 |
DOI(出版社版): | 10.1111/cas.13892 |
PubMed ID: | 30485606 |
出現コレクション: | 学術雑誌掲載論文等 |
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