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Title: A cis‐acting bidirectional transcription switch controls sexual dimorphism in the liverwort
Authors: Hisanaga, Tetsuya
Okahashi, Keitaro
Yamaoka, Shohei  kyouindb  KAKEN_id
Kajiwara, Tomoaki
Nishihama, Ryuichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Shimamura, Masaki
Yamato, Katsuyuki T
Bowman, John L
Kohchi, Takayuki  kyouindb  KAKEN_id  orcid (unconfirmed)
Nakajima, Keiji
Author's alias: 久永, 哲也
岡橋, 啓太郎
山岡, 尚平
梶原, 智明
西浜, 竜一
嶋村, 正樹
大和, 勝幸
ボーマン, ジョン
河内, 孝之
中島, 敬二
Keywords: antisense transcription
Marchantia polymorpha
R2R3 MYB-type transcription factor
sexual differentiation
Issue Date: 15-Mar-2019
Publisher: EMBO
Journal title: The EMBO Journal
Volume: 38
Issue: 6
Thesis number: e100240
Abstract: Plant life cycles alternate between haploid gametophytes and diploid sporophytes. While regulatory factors determining male and female sexual morphologies have been identified for sporophytic reproductive organs, such as stamens and pistils of angiosperms, those regulating sex‐specific traits in the haploid gametophytes that produce male and female gametes and hence are central to plant sexual reproduction are poorly understood. Here, we identified a MYB‐type transcription factor, MpFGMYB, as a key regulator of female sexual differentiation in the haploid‐dominant dioicous liverwort, Marchantia polymorpha. MpFGMYB is specifically expressed in females and its loss resulted in female‐to‐male sex conversion. Strikingly, MpFGMYB expression is suppressed in males by a cis‐acting antisense gene SUF at the same locus, and loss‐of‐function suf mutations resulted in male‐to‐female sex conversion. Thus, the bidirectional transcription module at the MpFGMYB/SUF locus acts as a toggle between female and male sexual differentiation in M. polymorpha gametophytes. Arabidopsis thaliana MpFGMYB orthologs are known to be expressed in embryo sacs and promote their development. Thus, phylogenetically related MYB transcription factors regulate female gametophyte development across land plants.
Description: ゼニゴケが遺伝子のオモテとウラを使ってメスとオスを作り分けていることを解明 --性差を生み出す巧妙な「裏ワザ」が明らかに--. 京都大学プレスリリース. 2019-01-09.
Rights: © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI(Published Version): 10.15252/embj.2018100240
PubMed ID: 30609993
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