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| ファイル | 記述 | サイズ | フォーマット | |
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| ncomms11008.pdf | 718.18 kB | Adobe PDF | 見る/開く |
| タイトル: | Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| 著者: | Fan, Qiao Verhoeven, Virginie J. M. Wojciechowski, Robert Barathi, Veluchamy A. Hysi, Pirro G. Guggenheim, Jeremy A. Höhn, René Vitart, Veronique Khawaja, Anthony P. Yamashiro, Kenji Hosseini, S Mohsen Lehtimäki, Terho Lu, Yi Haller, Toomas Xie, Jing Delcourt, Cécile Pirastu, Mario Wedenoja, Juho Gharahkhani, Puya Venturini, Cristina Miyake, Masahiro   Hewitt, Alex W. Guo, Xiaobo Mazur, Johanna Huffman, Jenifer E. Williams, Katie M. Polasek, Ozren Campbell, Harry Rudan, Igor Vatavuk, Zoran Wilson, James F. Joshi, Peter K. McMahon, George St Pourcain, Beate Evans, David M. Simpson, Claire L. Schwantes-An, Tae-Hwi Igo, Robert P. Mirshahi, Alireza Cougnard-Gregoire, Audrey Bellenguez, Céline Blettner, Maria Raitakari, Olli Kähönen, Mika Seppälä, Ilkka Zeller, Tanja Meitinger, Thomas Ried, Janina S. Gieger, Christian Portas, Laura van Leeuwen, Elisabeth M. Amin, Najaf Uitterlinden, André G. Rivadeneira, Fernando Hofman, Albert Vingerling, Johannes R. Wang, Ya Xing Wang, Xu Tai-Hui Boh, Eileen Ikram, M. Kamran Sabanayagam, Charumathi Gupta, Preeti Tan, Vincent Zhou, Lei Ho, Candice E. H. Lim, Wan’e Beuerman, Roger W. Siantar, Rosalynn Tai, E-Shyong Vithana, Eranga Mihailov, Evelin Khor, Chiea-Chuen Hayward, Caroline Luben, Robert N. Foster, Paul J. Klein, Barbara E. K. Klein, Ronald Wong, Hoi-Suen Mitchell, Paul Metspalu, Andres Aung, Tin Young, Terri L. He, Mingguang Pärssinen, Olavi van Duijn, Cornelia M. Jin Wang, Jie Williams, Cathy Jonas, Jost B. Teo, Yik-Ying Mackey, David A. Oexle, Konrad Yoshimura, Nagahisa Paterson, Andrew D. Pfeiffer, Norbert Wong, Tien-Yin Baird, Paul N. Stambolian, Dwight Wilson, Joan E. Bailey Cheng, Ching-Yu Hammond, Christopher J. Klaver, Caroline C. W. Saw, Seang-Mei |
| 著者名の別形: | 山城, 健児 三宅, 正裕 吉村, 長久 |
| キーワード: | Education Genetic variation Genome-wide association studies Refractive errors |
| 発行日: | 6-Apr-2016 |
| 出版者: | Springer Nature America, Inc |
| 誌名: | Nature Communications |
| 巻: | 7 |
| 開始ページ: | 11008 |
| 抄録: | Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40, 036 adults from 25 studies of European ancestry and 10, 315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10−5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. |
| 著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| URI: | http://hdl.handle.net/2433/236005 |
| DOI(出版社版): | 10.1038/ncomms11008 |
| PubMed ID: | 27020472 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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