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タイトル: Abnormal Outer Choroidal Vasculature in Amblyopia
著者: Terada, Noriko
Miyata, Manabu  kyouindb  KAKEN_id
Muraoka, Yuki
Hata, Masayuki
Fujimoto, Masahiro
Yokota, Satoshi
Nakanishi, Hideo
Suda, Kenji
Yoshikawa, Munemitsu
Ooto, Sotaro
Ohtsuki, Hiroshi
Tsujikawa, Akitaka
著者名の別形: 寺田, 紀子
宮田, 学
村岡, 勇貴
畑, 匡侑
藤本, 雅大
横田, 聡
中西, 秀雄
須田, 謙史
大音, 壮太郎
辻川, 明孝
発行日: 10-Jan-2019
出版者: Hindawi Limited
誌名: Journal of Ophthalmology
巻: 2019
論文番号: 209787
抄録: Purpose. Several studies have indicated morphological changes in the choroid in amblyopia cases. This study investigates whether choroidal vasculature was different among amblyopic and fellow eyes in unilateral amblyopia patients and healthy eyes, using en face images acquired via swept-source optical coherence tomography (SS-OCT). Design. Prospective, observational case-control study. Methods. This study included 14 consecutive patients with unilateral amblyopia and 22 age- and axial length-matched healthy eyes. Using SS-OCT, we obtained en face images of choroidal vasculature midway through the subfoveal inner and total choroid, corresponding to the vasculature of the choriocapillaris and Sattler’s layer (inner choroid) and Haller’s layer (outer choroid), respectively. We analyzed the en face images of the inner and outer choroidal vascular areas in 3 × 3 mm squares adjusted from 6 × 6 mm squares, using Littmann’s magnification correction, after binarization of the images as a portion of the whole area. Results. The outer choroidal vascular areas were larger in both amblyopic and fellow eyes than in healthy eyes (both P<0.001), although there were no significant differences in inner (56.35 ± 2.46% and 56.27 ± 3.75%, respectively) or outer (61.49 ± 4.95% and 61.48 ± 3.73%, respectively) choroidal vascular area between amblyopic and fellow eyes (P = 0.98 and 0.91, respectively). An outer choroidal vascular area of 59% was set as an appropriate cutoff value for distinguishing patients from controls. Conclusions. The outer choroidal vascular area was larger in both amblyopic eyes and fellow eyes compared to healthy eyes. Our findings may help clarify the etiology of amblyopia.
著作権等: Copyright © 2019 Noriko Terada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/236016
DOI(出版社版): 10.1155/2019/2097087
出現コレクション:学術雑誌掲載論文等

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