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タイトル: Factors Associated with Increased Levels of Brain Natriuretic Peptide and Cardiac Troponin I during the Peripartum Period
著者: Kimura, Yuki
Kato, Takao  kyouindb  KAKEN_id
Miyata, Hiromi
Sasaki, Issei
Minamino-Muta, Eri
Nagasawa, Yoshinori
Numao, Shigeharu
Nagano, Tadayoshi
Higuchi, Toshihiro
Inoko, Moriaki
著者名の別形: 加藤, 貴雄
発行日: 7-Feb-2019
出版者: Public Library of Science (PLoS)
誌名: PLOS ONE
巻: 14
号: 2
論文番号: e0211982
抄録: Background: We aimed to investigate the values and the changes of brain natriuretic peptide (BNP) and cardiac troponin in pregnant women. Methods and results: We prospectively collected the data of 405 pregnant women who were treated at Japanese general hospital between 2012 and 2013. We analyzed their laboratory data and echocardiographic findings during the third trimester (28–30 weeks’ gestation) and within 4 days of delivery. In addition, we evaluated the factors associated with elevation of BNP and cardiac troponin I (cTnI) levels. The pregnant women were 33.8 ± 5.0 years old and the prevalence of pregnancy induced hypertension (PIH) and placental abnormality was 4.2% and 2.5%, respectively. BNP levels increased after delivery (13.2 pg/mL vs. 23.5 pg/mL; P <0.001), correlated with increased left ventricular diastolic dimension (P = 0.035), left atrial dimension (P <0.001), and decreased hemoglobin (P <0.001). Moreover, cTnI levels increased to over 0.015 ng/mL after delivery in 4.0% of pregnant women. In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. Conclusions: BNP levels increased in association with cardiac chamber enlargement and decreased hemoglobin after delivery. Additionally, the factors affecting elevated cTnI levels were related to labor and delivery.
著作権等: © 2019 Kimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/236374
DOI(出版社版): 10.1371/journal.pone.0211982
出現コレクション:学術雑誌掲載論文等

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