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タイトル: Medusavirus, a novel large DNA virus discovered from hot spring water
著者: Yoshikawa, Genki
Blanc-Mathieu, Romain
Song, Chihong
Kayama, Yoko
Mochizuki, Tomohiro
Murata, Kazuyoshi
Ogata, Hiroyuki
Takemura, Masaharu
著者名の別形: 吉川, 元貴
ブランマチュー, ロマン
宋, 致宖
香山, 容子
望月, 智弘
村田, 和義
緒方, 博之
武村, 政春
発行日: 6-Feb-2019
出版者: American Society for Microbiology
誌名: Journal of Virology
抄録: Recent discoveries of new large DNA viruses reveal high diversity in their morphologies, genetic repertoires, and replication strategies. Here, we report the novel features of Medusavirus, a large DNA virus newly isolated from hot spring water in Japan. Medusavirus with a diameter of 260 nm shows a T=277 icosahedral capsid with unique spherical-headed spikes on its surface. It has a 381 kb genome encoding 461 putative proteins, 86 of which have their closest homologs in Acanthamoeba castellanii, whereas 279 (61%) are ORFans. The virus lacking the genes of DNA topoisomerase II and RNA polymerase showed that the DNA replication takes place in the host nucleus while the progeny virions are assembled in the cytoplasm. Furthermore, Medusavirus encoded all of five types of histones (H1, H2A, H2B, H3, and H4) and one DNA polymerase, which are phylogenetically placed at the root of the eukaryotic clades. By contrast, the host amoeba encoded many Medusavirus homologs including the major capsid protein. These facts strongly suggested that amoeba is indeed the most promising natural host of Medusavirus, and lateral gene transfers have taken place repeatedly and bidirectionally between the virus and its host since the early stage of their co-evolution. Medusavirus reflects the traces of direct evolutionary interactions between the virus and eukaryotic hosts, which may be caused by sharing the DNA replication compartment and evolutionarily long lasting viral-host relationships. Based on its unique morphological characteristics and phylogenomic relationships with other known large DNA viruses, we propose that Medusavirus forms a new family Medusaviridae.
記述: ヒストン遺伝子を全セット持つ巨大ウイルスの発見 --DNA関連遺伝子のウイルス起源に新たな証拠--. 京都大学プレスリリース. 2019-02-08.
著作権等: © 2019 Yoshikawa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
URI: http://hdl.handle.net/2433/236380
DOI(出版社版): 10.1128/JVI.02130-18
PubMed ID: 30728258
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2018/190206_2.html
出現コレクション:学術雑誌掲載論文等

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