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Title: Anemia in Patients with Severe Aortic Stenosis
Authors: Nagao, Kazuya
Taniguchi, Tomohiko
Morimoto, Takeshi
Shiomi, Hiroki  kyouindb  KAKEN_id
Ando, Kenji
Kanamori, Norio
Murata, Koichiro
Kitai, Takeshi
Kawase, Yuichi
Izumi, Chisato
Miyake, Makoto
Mitsuoka, Hirokazu
Kato, Masashi
Hirano, Yutaka
Matsuda, Shintaro
Inada, Tsukasa
Murakami, Tomoyuki
Takeuchi, Yasuyo
Yamane, Keiichiro
Toyofuku, Mamoru
Ishii, Mitsuru
Minamino-Muta, Eri
Kato, Takao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8213-7999 (unconfirmed)
Inoko, Moriaki
Ikeda, Tomoyuki
Komasa, Akihiro
Ishii, Katsuhisa
Hotta, Kozo
Higashitani, Nobuya
Kato, Yoshihiro
Inuzuka, Yasutaka
Maeda, Chiyo
Jinnai, Toshikazu
Morikami, Yuko
Saito, Naritatsu
Minatoya, Kenji
Kimura, Takeshi  kyouindb  KAKEN_id
CURRENT AS Registry Investigators
Author's alias: 加藤, 貴雄
齋藤, 成達
木村, 剛
Keywords: Outcomes research
Valvular disease
Issue Date: 13-Feb-2019
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 9
Thesis number: 1924
Abstract: Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.
Rights: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/236492
DOI(Published Version): 10.1038/s41598-018-36066-z
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