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タイトル: | Japanese multicenter database of healthy controls for [¹²³I]FP-CIT SPECT |
著者: | Matsuda, Hiroshi Murata, Miho Mukai, Yohei Sako, Kazuya Ono, Hidetoshi Toyama, Hiroshi Inui, Yoshitaka Taki, Yasuyuki Shimomura, Hideo Nagayama, Hiroshi Tateno, Amane Ono, Kenjiro Murakami, Hidetomo Kono, Atsushi Hirano, Shigeki Kuwabara, Satoshi Maikusa, Norihide Ogawa, Masayo Imabayashi, Etsuko Sato, Noriko Takano, Harumasa Hatazawa, Jun Takahashi, Ryosuke https://orcid.org/0000-0002-1407-9640 (unconfirmed) |
著者名の別形: | 髙橋, 良輔 |
キーワード: | Multicenter trial SPECT [¹²³I]FP-CIT Normal database Dopamine transporter |
発行日: | Jul-2018 |
出版者: | Springer Nature |
誌名: | European journal of nuclear medicine and molecular imaging |
巻: | 45 |
号: | 8 |
開始ページ: | 1405 |
終了ページ: | 1416 |
抄録: | Purpose: The aim of this multicenter trial was to generate a [¹²³I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group. Conclusions: This study provided a large-scale quantitative database of [¹²³I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database. |
著作権等: | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
URI: | http://hdl.handle.net/2433/236659 |
DOI(出版社版): | 10.1007/s00259-018-3976-5 |
PubMed ID: | 29478082 |
出現コレクション: | 学術雑誌掲載論文等 |
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