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Title: Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene
Authors: Takigawa, Yuki
Fujiwara, Keiichi
Saito, Takashi
Nakasuka, Takamasa
Ozeki, Taichi
Okawa, Sachi
Takada, Kenji
Iwamoto, Yoshitaka
Kayatani, Hiroe
Minami, Daisuke
Sato, Ken
Nagao, Miki
Shibayama, Takuo
Author's alias: 長尾, 美紀
Keywords: community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)
Panton-Valentine leukocidine (PVL) gene
necrotizing pneumonia
multiple cavity formation
Issue Date: 1-Mar-2019
Publisher: NLM (Medline)
Journal title: Internal Medicine
Volume: 58
Issue: 5
Start page: 685
End page: 691
Abstract: A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes encoding Panton-Valentine leucocidin (PVL). CA-MRSA necrotizing pneumonia with the PVL gene is rare; only three cases have been previously reported in Japan. We administered anti-MRSA antibiotics and the patient achieved complete clinical and radiological improvement.
Rights: The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (
DOI(Published Version): 10.2169/internalmedicine.1454-18
PubMed ID: 30333405
Appears in Collections:Journal Articles

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