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タイトル: | Antibacterial activity of nanoporous gold against Escherichia coli and Staphylococcus epidermidis |
著者: | Hakamada, Masataka https://orcid.org/0000-0002-8082-2148 (unconfirmed) Taniguchi, Seiji Mabuchi, Mamoru https://orcid.org/0000-0002-0894-6306 (unconfirmed) |
著者名の別形: | 袴田, 昌高 谷口, 清二 馬渕, 守 |
キーワード: | nanostructure Au biological |
発行日: | 15-May-2017 |
出版者: | Cambridge University Press |
誌名: | Journal of Materials Research |
巻: | 32 |
号: | 9 |
開始ページ: | 1787 |
終了ページ: | 1795 |
抄録: | Conventional metallic antibacterial materials release metal ions and reactive oxygen species (ROS) for killing bacteria. Herein, we found that nanoporous gold (NPG) exhibits antibacterial activity (AA) at an intermediate relative humidity (RH) of 60% against Escherichia coli and Staphylococcus epidermidis in contrast to the inert behavior of bulk gold. The dependence of AA on RH, morphological observations of bacteria on NPG, and transcriptomic analyses of NPG-treated Escherichia coli were investigated. These observations collectively suggest that biological processes in cell walls containing peptidoglycan and cell membranes are significantly disrupted by direct contact with NPG. Metal ions and ROS were not detected, and therefore are not responsible for the present antibacterial properties of NPG. The catalytic nature of NPG may be responsible for its AA, probably because of lattice distortion at the surface of nanosized ligaments with large curvature. |
著作権等: | This article has been published in a revised form in 'Journal of Materials Research', https://doi.org/10.1557/jmr.2017.157. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Materials Research Society. The full-text file will be made open to the public on 16 November 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/237615 |
DOI(出版社版): | 10.1557/jmr.2017.157 |
出現コレクション: | 学術雑誌掲載論文等 |
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