ダウンロード数: 251
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.neuroscience.2019.04.012.pdf | 1.07 MB | Adobe PDF | 見る/開く |
タイトル: | Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice |
著者: | Kakae, Masashi Miyanohara, Jun Morishima, Misa Nagayasu, Kazuki https://orcid.org/0000-0002-7438-732X (unconfirmed) Mori, Yasuo Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed) Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
著者名の別形: | 森嶋, 美沙 永安, 一樹 森, 泰生 白川, 久志 金子, 周司 |
キーワード: | aging cognitive impairment white matter injury TRPM2 microglia cytokines |
発行日: | 1-Jun-2019 |
出版者: | Elsevier Ltd |
誌名: | Neuroscience |
巻: | 408 |
開始ページ: | 204 |
終了ページ: | 213 |
抄録: | Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia plays a critical role in exacerbating inflammation, white matter injury, and cognitive impairment during chronic cerebral hypoperfusion; however, the physiological or pathophysiological role of TRPM2 during age-associated inflammatory responses remains unclear. Therefore, we examined the effects of TRPM2 deletion in young (2–3 months) and older (12–24 months) mice. Compared with young wild-type (WT) mice, middle-aged (12–16 months) WT mice showed working and cognitive memory dysfunction and aged (20–24 months) WT mice exhibited impaired spatial memory. However, these characteristics were not seen in TRPM2 knockout (TRPM2-KO) mice. Consistent with the finding of cognitive impairment, aged WT mice exhibited white matter injury and hippocampal damage and an increase in the number of Iba1-positive cells and amounts of pro-inflammatory cytokines in the brain; these characteristics were not seen in TRPM2-KO mice. These findings suggest that TRPM2 plays a critical role in exacerbating inflammatory responses and cognitive dysfunction during aging. |
著作権等: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 June 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/241618 |
DOI(出版社版): | 10.1016/j.neuroscience.2019.04.012 |
PubMed ID: | 30999030 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。